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4EMZ

HIV-1 Nef in complex with MHC-I cytoplasmic domain and Mu1 adaptin subunit of AP1 adaptor (second domain)

Functional Information from GO Data
ChainGOidnamespacecontents
A0006886biological_processintracellular protein transport
A0016192biological_processvesicle-mediated transport
A0030131cellular_componentclathrin adaptor complex
B0005102molecular_functionsignaling receptor binding
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005576cellular_componentextracellular region
B0010561biological_processnegative regulation of glycoprotein biosynthetic process
B0016020cellular_componentmembrane
B0017124molecular_functionSH3 domain binding
B0019058biological_processviral life cycle
B0019901molecular_functionprotein kinase binding
B0020002cellular_componenthost cell plasma membrane
B0031996molecular_functionthioesterase binding
B0033644cellular_componenthost cell membrane
B0033668biological_processsymbiont-mediated suppression of host apoptosis
B0039504biological_processsymbiont-mediated suppression of host adaptive immune response
B0039505biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
B0042288molecular_functionMHC class I protein binding
B0042609molecular_functionCD4 receptor binding
B0044177cellular_componenthost cell Golgi apparatus
B0044178cellular_componenthost cell Golgi membrane
B0044423cellular_componentvirion component
B0046776biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
B0050848biological_processregulation of calcium-mediated signaling
B0051117molecular_functionATPase binding
B0051701biological_processbiological process involved in interaction with host
B0052170biological_processsymbiont-mediated suppression of host innate immune response
B0070206biological_processprotein trimerization
B0140321biological_processsymbiont-mediated suppression of host autophagy
C0005102molecular_functionsignaling receptor binding
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005576cellular_componentextracellular region
C0010561biological_processnegative regulation of glycoprotein biosynthetic process
C0016020cellular_componentmembrane
C0017124molecular_functionSH3 domain binding
C0019058biological_processviral life cycle
C0019901molecular_functionprotein kinase binding
C0020002cellular_componenthost cell plasma membrane
C0031996molecular_functionthioesterase binding
C0033644cellular_componenthost cell membrane
C0033668biological_processsymbiont-mediated suppression of host apoptosis
C0039504biological_processsymbiont-mediated suppression of host adaptive immune response
C0039505biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
C0042288molecular_functionMHC class I protein binding
C0042609molecular_functionCD4 receptor binding
C0044177cellular_componenthost cell Golgi apparatus
C0044178cellular_componenthost cell Golgi membrane
C0044423cellular_componentvirion component
C0046776biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
C0050848biological_processregulation of calcium-mediated signaling
C0051117molecular_functionATPase binding
C0051701biological_processbiological process involved in interaction with host
C0052170biological_processsymbiont-mediated suppression of host innate immune response
C0070206biological_processprotein trimerization
C0140321biological_processsymbiont-mediated suppression of host autophagy
D0006955biological_processimmune response
D0019882biological_processantigen processing and presentation
E0006955biological_processimmune response
E0019882biological_processantigen processing and presentation
M0006886biological_processintracellular protein transport
M0016192biological_processvesicle-mediated transport
M0030131cellular_componentclathrin adaptor complex
Functional Information from PROSITE/UniProt
site_idPS00991
Number of Residues15
DetailsCLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. IsFIPPdGeFeLmsY
ChainResidueDetails
AILE253-TYR267

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
DSER319
DGLY325
DSER326
DSER328
ESER319
EGLY325
ESER326
ESER328

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569
ChainResidueDetails
DTYR320
ETYR320

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
DSER332
DSER335
ESER332
ESER335

237423

PDB entries from 2025-06-11

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