8Q8N
| Crystal structure of human GPX4-U46C-I129S-L130S | 分子名称: | Phospholipid hydroperoxide glutathione peroxidase | 著者 | Bostock, M.J, Mourao, A, Napolitano, V, Sattler, M, Conrad, M, Popowicz, G. | 登録日 | 2023-08-18 | 公開日 | 2024-08-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | An ultra-rare variant of GPX4 reveals the structural basis to avert neurodegeneration To Be Published
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8Q8J
| Crystal structure of human GPX4-R152H | 分子名称: | Glutathione peroxidase | 著者 | Napolitano, V, Mourao, A, Kolonko, M, Bostock, M.J, Sattler, M, Conrad, M, Popowicz, G. | 登録日 | 2023-08-18 | 公開日 | 2024-08-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of human GPX4-R152H To Be Published
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7U4N
| Crystal structure of human GPX4-U46C in complex with RSL3 | 分子名称: | Phospholipid hydroperoxide glutathione peroxidase, methyl (1S,3R)-2-(chloroacetyl)-1-[4-(methoxycarbonyl)phenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate | 著者 | Forouhar, F, Liu, H, Lin, A.J, Wang, Q, Xia, X, Soni, R.K, Stockwell, B.R. | 登録日 | 2022-02-28 | 公開日 | 2022-12-07 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29, 2022
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7U4M
| Crystal structure of human GPX4-U46C in complex with LOC1886 | 分子名称: | 1,2-ETHANEDIOL, 4-methoxy-1H-indole-2-carbaldehyde, Phospholipid hydroperoxide glutathione peroxidase | 著者 | Forouhar, F, Liu, H, Lin, A.J, Wang, Q, Polychronidou, V, Soni, R.K, Xia, X, Stockwell, B.R. | 登録日 | 2022-02-28 | 公開日 | 2022-12-07 | 最終更新日 | 2022-12-28 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29, 2022
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7U4L
| Crystal structure of human GPX4-U46C in complex with MAC-5576 | 分子名称: | Phospholipid hydroperoxide glutathione peroxidase, thiophene-2-carbaldehyde | 著者 | Forouhar, F, Liu, H, Lin, A.J, Wang, Q, Polychronidou, V, Soni, R.K, Xia, X, Stockwell, B.R. | 登録日 | 2022-02-28 | 公開日 | 2022-12-07 | 最終更新日 | 2022-12-28 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29, 2022
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7U4K
| Crystal structure of human GPX4-U46C-R152H in complex with ML162 | 分子名称: | 1,2-ETHANEDIOL, 2-chloro-N-(3-chloro-4-methoxyphenyl)-N-[(1R)-2-oxo-2-[(2-phenylethyl)amino]-1-(thiophen-2-yl)ethyl]acetamide, Phospholipid hydroperoxide glutathione peroxidase | 著者 | Forouhar, F, Liu, H, Lin, A.J, Wang, Q, Xia, X, Soni, R.K, Stockwell, B.R. | 登録日 | 2022-02-28 | 公開日 | 2022-12-07 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29, 2022
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7U4J
| Crystal structure of human GPX4-U46C-R152H in complex with TMT10 | 分子名称: | Phospholipid hydroperoxide glutathione peroxidase, THIOCYANATE ION, ~{N}-(3-chloranyl-4-methoxy-phenyl)ethanamide | 著者 | Forouhar, F, Liu, H, Lin, A.J, Wang, Q, Polychronidou, V, Soni, R.K, Xia, X, Stockwell, B.R. | 登録日 | 2022-02-28 | 公開日 | 2022-12-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29, 2022
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7U4I
| Crystal structure of human GPX4-U46C-R152H in complex with CDS9 | 分子名称: | 2-bromo-N-[(thiophen-2-yl)methyl]acetamide, Phospholipid hydroperoxide glutathione peroxidase, THIOCYANATE ION | 著者 | Forouhar, F, Liu, H, Lin, A.J, Wang, Q, Polychronidou, V, Soni, R.K, Xia, X, Stockwell, B.R. | 登録日 | 2022-02-28 | 公開日 | 2022-12-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29, 2022
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7L8R
| Crystal structure of human GPX4-U46C mutant K48A | 分子名称: | Isoform Cytoplasmic of Phospholipid hydroperoxide glutathione peroxidase, THIOCYANATE ION | 著者 | Forouhar, F, Liu, H, Seibt, T, Saneto, R, Wigby, K, Friedman, J, Xia, X, Shchepinov, M.S, Ramesh, S, Conrad, M, Stockwell, B.R. | 登録日 | 2020-12-31 | 公開日 | 2021-12-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Patient-derived variant of GPX4 reveals the structural basis for its catalytic activity and degradation mechanism Nat.Chem.Biol., 2021
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7L8Q
| Crystal structure of human GPX4-U46C with oxidized Cys-46 | 分子名称: | ACETATE ION, Phospholipid hydroperoxide glutathione peroxidase | 著者 | Forouhar, F, Liu, H, Seibt, T, Saneto, R, Wigby, K, Friedman, J, Xia, X, Shchepinov, M.S, Ramesh, S, Conrad, M, Stockwell, B.R. | 登録日 | 2020-12-31 | 公開日 | 2021-12-29 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Patient-derived variant of GPX4 reveals the structural basis for its catalytic activity and degradation mechanism Nat.Chem.Biol., 2021
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7L8M
| Crystal structure of human GPX4-U46C mutant K48L | 分子名称: | Phospholipid hydroperoxide glutathione peroxidase | 著者 | Forouhar, F, Liu, H, Seibt, T, Saneto, R, Friedman, J, Xia, X, Shchepinov, M.S, Ramesh, S, Conrad, M, Stockwell, B.R. | 登録日 | 2020-12-31 | 公開日 | 2021-12-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Patient-derived variant of GPX4 reveals the structural basis for its catalytic activity and degradation mechanism Nat.Chem.Biol., 2021
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7L8L
| Crystal structure of human R152H GPX4-U46C | 分子名称: | Phospholipid hydroperoxide glutathione peroxidase, THIOCYANATE ION | 著者 | Forouhar, F, Liu, H, Seibt, T, Saneto, R, Wigby, K, Friedman, J, Xia, X, Shchepinov, M.S, Ramesh, S, Conrad, M, Stockwell, B.R. | 登録日 | 2020-12-31 | 公開日 | 2021-12-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Patient-derived variant of GPX4 reveals the structural basis for its catalytic activity and degradation mechanism Nat.Chem.Biol., 2021
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7L8K
| Crystal structure of human GPX4-U46C | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, PHOSPHATE ION, ... | 著者 | Forouhar, F, Liu, H, Seibt, T, Saneto, R, Wigby, K, Friedman, J, Xia, X, Shchepinov, M.S, Ramesh, S, Conrad, M, Stockwell, B.R. | 登録日 | 2020-12-31 | 公開日 | 2021-12-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Patient-derived variant of GPX4 reveals the structural basis for its catalytic activity and degradation mechanism Nat.Chem.Biol., 2021
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7FC2
| Crystal Structure of GPX6 | 分子名称: | Glutathione peroxidase 6, SULFATE ION | 著者 | Sun, J. | 登録日 | 2021-07-13 | 公開日 | 2022-07-20 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of GPX6 To Be Published
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6VPD
| Crystal structure of Trgpx in apo form | 分子名称: | Glutathione peroxidase | 著者 | Adriani, P.P, De Oliveira, G.S, Paiva, F.C.R, Dias, M.V.B, Chambergo, F.S. | 登録日 | 2020-02-03 | 公開日 | 2020-12-16 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.603 Å) | 主引用文献 | Structural and functional characterization of the glutathione peroxidase-like thioredoxin peroxidase from the fungus Trichoderma reesei. Int.J.Biol.Macromol., 167, 2020
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6HN3
| wildtype form (apo) of human GPX4 with Se-Cys46 | 分子名称: | CHLORIDE ION, ETHANOL, GLYCEROL, ... | 著者 | Hillig, R.C, Moosmayer, D, Hilpmann, A, Hoffmann, J, Schnirch, L, Eaton, J.K, Badock, V, Gradl, S. | 登録日 | 2018-09-13 | 公開日 | 2020-04-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.01 Å) | 主引用文献 | Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162. Acta Crystallogr D Struct Biol, 77, 2021
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6HKQ
| Human GPX4 in complex with covalent Inhibitor ML162 (S enantiomer) | 分子名称: | (2~{S})-2-[2-chloranylethanoyl-(3-chloranyl-4-methoxy-phenyl)amino]-~{N}-(2-phenylethyl)-2-thiophen-2-yl-ethanamide, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... | 著者 | Hillig, R.C, Moosmayer, D, Hilpmann, A, Hoffmann, L, Schnirch, L, Eaton, J.K, Badock, V, Gradl, S. | 登録日 | 2018-09-07 | 公開日 | 2020-04-01 | 最終更新日 | 2022-12-07 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162. Acta Crystallogr D Struct Biol, 77, 2021
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6ELW
| High resolution structure of selenocysteine containing human GPX4 | 分子名称: | CHLORIDE ION, Phospholipid hydroperoxide glutathione peroxidase, mitochondrial | 著者 | Kalms, J, Borchert, A, Kuhn, H, Scheerer, P. | 登録日 | 2017-09-29 | 公開日 | 2018-06-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction. Biochim. Biophys. Acta, 1863, 2018
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5L71
| Crystal structure of mouse phospholipid hydroperoxide glutathione peroxidase 4 (GPx4) | 分子名称: | 1,2-ETHANEDIOL, Phospholipid hydroperoxide glutathione peroxidase, mitochondrial | 著者 | Janowski, R, Scanu, S, Madl, T, Niessing, D. | 登録日 | 2016-06-01 | 公開日 | 2016-10-19 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4. Acta Crystallogr.,Sect.F, 72, 2016
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5H5S
| Crystal structure of human GPX4 in complex with GXpep-3 | 分子名称: | GLYCEROL, GXpep-3, Phospholipid hydroperoxide glutathione peroxidase, ... | 著者 | Sogabe, S, Kadotani, A, Lane, W, Snell, G. | 登録日 | 2016-11-09 | 公開日 | 2016-12-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis Biochem. Biophys. Res. Commun., 482, 2017
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5H5R
| Crystal structure of human GPX4 in complex with GXpep-2 | 分子名称: | GLYCEROL, GXpep-2, Phospholipid hydroperoxide glutathione peroxidase, ... | 著者 | Sogabe, S, Kadotani, A, Lane, W, Snell, G. | 登録日 | 2016-11-09 | 公開日 | 2016-12-07 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis Biochem. Biophys. Res. Commun., 482, 2017
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5H5Q
| Crystal structure of human GPX4 in complex with GXpep-1 | 分子名称: | GLYCEROL, GXpep-1, Phospholipid hydroperoxide glutathione peroxidase, ... | 著者 | Sogabe, S, Kadotani, A, Lane, W, Snell, G. | 登録日 | 2016-11-09 | 公開日 | 2016-12-07 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis Biochem. Biophys. Res. Commun., 482, 2017
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3KIJ
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3E0U
| Crystal structure of T. cruzi GPX1 | 分子名称: | AMMONIUM ION, GLYCEROL, Glutathione peroxidase | 著者 | Patel, S.H, Hussain, S, Harris, R, Driscoll, P, Djordjevic, S. | 登録日 | 2008-08-01 | 公開日 | 2009-08-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I). Biochem.J., 425, 2010
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3DWV
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