7U4K
Crystal structure of human GPX4-U46C-R152H in complex with ML162
Summary for 7U4K
Entry DOI | 10.2210/pdb7u4k/pdb |
Descriptor | Phospholipid hydroperoxide glutathione peroxidase, 2-chloro-N-(3-chloro-4-methoxyphenyl)-N-[(1R)-2-oxo-2-[(2-phenylethyl)amino]-1-(thiophen-2-yl)ethyl]acetamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | gpx4, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 22470.59 |
Authors | Forouhar, F.,Liu, H.,Lin, A.J.,Wang, Q.,Xia, X.,Soni, R.K.,Stockwell, B.R. (deposition date: 2022-02-28, release date: 2022-12-07, Last modification date: 2024-10-09) |
Primary citation | Liu, H.,Forouhar, F.,Lin, A.J.,Wang, Q.,Polychronidou, V.,Soni, R.K.,Xia, X.,Stockwell, B.R. Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29:1680-1693.e9, 2022 Cited by PubMed: 36423641DOI: 10.1016/j.chembiol.2022.11.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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