7U4K

Crystal structure of human GPX4-U46C-R152H in complex with ML162

Summary for 7U4K

Entry DOI	10.2210/pdb7u4k/pdb
Descriptor	Phospholipid hydroperoxide glutathione peroxidase, 2-chloro-N-(3-chloro-4-methoxyphenyl)-N-[(1R)-2-oxo-2-[(2-phenylethyl)amino]-1-(thiophen-2-yl)ethyl]acetamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	gpx4, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	22470.59
Authors	Forouhar, F.,Liu, H.,Lin, A.J.,Wang, Q.,Xia, X.,Soni, R.K.,Stockwell, B.R. (deposition date: 2022-02-28, release date: 2022-12-07, Last modification date: 2023-10-25)
Primary citation	Liu, H.,Forouhar, F.,Lin, A.J.,Wang, Q.,Polychronidou, V.,Soni, R.K.,Xia, X.,Stockwell, B.R. Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29:1680-1693.e9, 2022 Cited by PubMed: 36423641 DOI: 10.1016/j.chembiol.2022.11.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.69 Å)

Structure validation