7U4L

Crystal structure of human GPX4-U46C in complex with MAC-5576

Summary for 7U4L

Entry DOI	10.2210/pdb7u4l/pdb
Descriptor	Phospholipid hydroperoxide glutathione peroxidase, thiophene-2-carbaldehyde (3 entities in total)
Functional Keywords	gpx4, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	88449.59
Authors	Forouhar, F.,Liu, H.,Lin, A.J.,Wang, Q.,Polychronidou, V.,Soni, R.K.,Xia, X.,Stockwell, B.R. (deposition date: 2022-02-28, release date: 2022-12-07, Last modification date: 2022-12-28)
Primary citation	Liu, H.,Forouhar, F.,Lin, A.J.,Wang, Q.,Polychronidou, V.,Soni, R.K.,Xia, X.,Stockwell, B.R. Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29:1680-1693.e9, 2022 Cited by PubMed: 36423641 DOI: 10.1016/j.chembiol.2022.11.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation