7U4L
Crystal structure of human GPX4-U46C in complex with MAC-5576
Summary for 7U4L
Entry DOI | 10.2210/pdb7u4l/pdb |
Descriptor | Phospholipid hydroperoxide glutathione peroxidase, thiophene-2-carbaldehyde (3 entities in total) |
Functional Keywords | gpx4, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 88449.59 |
Authors | Forouhar, F.,Liu, H.,Lin, A.J.,Wang, Q.,Polychronidou, V.,Soni, R.K.,Xia, X.,Stockwell, B.R. (deposition date: 2022-02-28, release date: 2022-12-07, Last modification date: 2022-12-28) |
Primary citation | Liu, H.,Forouhar, F.,Lin, A.J.,Wang, Q.,Polychronidou, V.,Soni, R.K.,Xia, X.,Stockwell, B.R. Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29:1680-1693.e9, 2022 Cited by PubMed: 36423641DOI: 10.1016/j.chembiol.2022.11.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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