5H5S

Crystal structure of human GPX4 in complex with GXpep-3

Summary for 5H5S

• Entry DOI: 10.2210/pdb5h5s/pdb
• Related: 5H5Q 5H5R
• Descriptor: Phospholipid hydroperoxide glutathione peroxidase, mitochondrial, GXpep-3, GLYCEROL, ... (4 entities in total)
• Functional Keywords: phospholipid hydroperoxide glutathione peroxidase 4, selenocysteine, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 21057.05

Authors

Sogabe, S.,Kadotani, A.,Lane, W.,Snell, G. (deposition date: 2016-11-09, release date: 2016-12-07, Last modification date: 2023-11-08)

• Primary citation: Sakamoto, K.,Sogabe, S.,Kamada, Y.,Matsumoto, S.I.,Kadotani, A.,Sakamoto, J.I.,Tani, A.; Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis; Biochem. Biophys. Res. Commun., 482:195-201, 2017; PubMed: 27836545; DOI: 10.1016/j.bbrc.2016.11.035

Experimental method

X-RAY DIFFRACTION (1.85 Å)