5H5S

Crystal structure of human GPX4 in complex with GXpep-3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0006979	biological_process	response to oxidative stress

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue GOL A 201

Chain	Residue
A	SER45
A	MET53
A	ASN55
A	GLU190
A	LYS191
A	HOH313

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Functional Information from PROSITE/UniProt

site_id	PS00460
Number of Residues	16
Details	GLUTATHIONE_PEROXID_1 Glutathione peroxidases active site. GFvSIVtNVaSqCGkT

Chain	Residue	Details
A	GLY61-THR76

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site_id	PS00763
Number of Residues	8
Details	GLUTATHIONE_PEROXID_2 Glutathione peroxidases signature 2. LAFPSNQF

Chain	Residue	Details
A	LEU98-PHE105

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:O70325

Chain	Residue	Details
A	CSD73

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P36970

Chain	Residue	Details
A	SER40

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