7U4I

Crystal structure of human GPX4-U46C-R152H in complex with CDS9

Summary for 7U4I

• Entry DOI: 10.2210/pdb7u4i/pdb
• Descriptor: Phospholipid hydroperoxide glutathione peroxidase, 2-bromo-N-[(thiophen-2-yl)methyl]acetamide, THIOCYANATE ION, ... (4 entities in total)
• Functional Keywords: gpx4, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 44322.49

Authors

Forouhar, F.,Liu, H.,Lin, A.J.,Wang, Q.,Polychronidou, V.,Soni, R.K.,Xia, X.,Stockwell, B.R. (deposition date: 2022-02-28, release date: 2022-12-07, Last modification date: 2023-10-25)

• Primary citation: Liu, H.,Forouhar, F.,Lin, A.J.,Wang, Q.,Polychronidou, V.,Soni, R.K.,Xia, X.,Stockwell, B.R.; Small-molecule allosteric inhibitors of GPX4.; Cell Chem Biol, 29:1680-1693.e9, 2022; PubMed: 36423641; DOI: 10.1016/j.chembiol.2022.11.003

Experimental method

X-RAY DIFFRACTION (1.97 Å)