7U4N
Crystal structure of human GPX4-U46C in complex with RSL3
Summary for 7U4N
| Entry DOI | 10.2210/pdb7u4n/pdb |
| Descriptor | Phospholipid hydroperoxide glutathione peroxidase, methyl (1S,3R)-2-(chloroacetyl)-1-[4-(methoxycarbonyl)phenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate (3 entities in total) |
| Functional Keywords | gpx4, oxidoreductase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 44657.95 |
| Authors | Forouhar, F.,Liu, H.,Lin, A.J.,Wang, Q.,Xia, X.,Soni, R.K.,Stockwell, B.R. (deposition date: 2022-02-28, release date: 2022-12-07, Last modification date: 2022-12-28) |
| Primary citation | Liu, H.,Forouhar, F.,Lin, A.J.,Wang, Q.,Polychronidou, V.,Soni, R.K.,Xia, X.,Stockwell, B.R. Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29:1680-1693.e9, 2022 Cited by PubMed: 36423641DOI: 10.1016/j.chembiol.2022.11.003 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report
