7U4N

Crystal structure of human GPX4-U46C in complex with RSL3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0006979	biological_process	response to oxidative stress
B	0004601	molecular_function	peroxidase activity
B	0006979	biological_process	response to oxidative stress

Functional Information from PROSITE/UniProt

site_id	PS00460
Number of Residues	16
Details	GLUTATHIONE_PEROXID_1 Glutathione peroxidases active site. GFvCIVtNVaSqCGkT

Chain	Residue	Details
A	GLY34-THR49

---

site_id	PS00763
Number of Residues	8
Details	GLUTATHIONE_PEROXID_2 Glutathione peroxidases signature 2. LAFPCNQF

Chain	Residue	Details
A	LEU71-PHE78

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:O70325

Chain	Residue	Details
A	CYS46
B	CYS46

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P36970

Chain	Residue	Details
A	SER13
B	SER13

---