7L8Q

Crystal structure of human GPX4-U46C with oxidized Cys-46

Summary for 7L8Q

• Entry DOI: 10.2210/pdb7l8q/pdb
• Descriptor: Phospholipid hydroperoxide glutathione peroxidase, ACETATE ION (3 entities in total)
• Functional Keywords: alpha-beta protein, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 22054.18

Authors

Forouhar, F.,Liu, H.,Seibt, T.,Saneto, R.,Wigby, K.,Friedman, J.,Xia, X.,Shchepinov, M.S.,Ramesh, S.,Conrad, M.,Stockwell, B.R. (deposition date: 2020-12-31, release date: 2021-12-29, Last modification date: 2023-11-15)

• Primary citation: Liu, H.,Forouhar, F.,Seibt, T.,Saneto, R.,Wigby, K.,Friedman, J.,Xia, X.,Shchepinov, M.S.,Ramesh, S.,Conrad, M.,Stockwell, B.R.; Patient-derived variant of GPX4 reveals the structural basis for its catalytic activity and degradation mechanism; Nat.Chem.Biol., 2021

Experimental method

X-RAY DIFFRACTION (1.48 Å)