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7L8R

Crystal structure of human GPX4-U46C mutant K48A

Summary for 7L8R
Entry DOI10.2210/pdb7l8r/pdb
DescriptorIsoform Cytoplasmic of Phospholipid hydroperoxide glutathione peroxidase, THIOCYANATE ION (3 entities in total)
Functional Keywordsalpha-beta protein, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight43718.07
Authors
Forouhar, F.,Liu, H.,Seibt, T.,Saneto, R.,Wigby, K.,Friedman, J.,Xia, X.,Shchepinov, M.S.,Ramesh, S.,Conrad, M.,Stockwell, B.R. (deposition date: 2020-12-31, release date: 2021-12-29, Last modification date: 2023-10-18)
Primary citationLiu, H.,Forouhar, F.,Seibt, T.,Saneto, R.,Wigby, K.,Friedman, J.,Xia, X.,Shchepinov, M.S.,Ramesh, S.,Conrad, M.,Stockwell, B.R.
Patient-derived variant of GPX4 reveals the structural basis for its catalytic activity and degradation mechanism
Nat.Chem.Biol., 2021
Experimental method
X-RAY DIFFRACTION (1.52 Å)
Structure validation

218853

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