6ELW
High resolution structure of selenocysteine containing human GPX4
Summary for 6ELW
Entry DOI | 10.2210/pdb6elw/pdb |
Descriptor | Phospholipid hydroperoxide glutathione peroxidase, mitochondrial, CHLORIDE ION (3 entities in total) |
Functional Keywords | human gpx4, peroxidase, selenoprotein, thioredoxin-fold, anti-oxidatve defense system, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 21912.96 |
Authors | Kalms, J.,Borchert, A.,Kuhn, H.,Scheerer, P. (deposition date: 2017-09-29, release date: 2018-06-20, Last modification date: 2024-01-17) |
Primary citation | Borchert, A.,Kalms, J.,Roth, S.R.,Rademacher, M.,Schmidt, A.,Holzhutter, H.G.,Kuhn, H.,Scheerer, P. Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction. Biochim. Biophys. Acta, 1863:1095-1107, 2018 Cited by PubMed: 29883798DOI: 10.1016/j.bbalip.2018.06.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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