6ELW

High resolution structure of selenocysteine containing human GPX4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	polymer	192	21806.6	1	UniProt (P36969) Pfam (PF00255)	Homo sapiens (Human)	PHGPx,Glutathione peroxidase 4,GSHPx-4
2	B, C, D (A)	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
3	E (A)	water	water		18.0	210	Chemie (HOH)

Sequence modifications

A: 2 - 170 (UniProt: P36969)

PDB	External Database	Details
Met -21	-	initiating methionine
Gly -20	-	expression tag
Ser -19	-	expression tag
Ser -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
Gly -9	-	expression tag
Leu -8	-	expression tag
Val -7	-	expression tag
Pro -6	-	expression tag
Arg -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
His -2	-	expression tag
Met -1	-	expression tag
Leu 0	-	expression tag
Glu 1	-	expression tag
Ala 2	Cys 2	engineered mutation
Ala 10	Cys 10	engineered mutation
Ser 37	Cys 37	engineered mutation
Ala 66	Cys 66	engineered mutation
Ser 75	Cys 75	engineered mutation
Ala 107	Cys 107	engineered mutation
Ala 148	Cys 148	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	21806.6
Non-Polymers*	Number of molecules	3
	Total formula weight	106.4
All*	Total formula weight	21913.0

*Water molecules are not included.