6ELW

High resolution structure of selenocysteine containing human GPX4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0006979	biological_process	response to oxidative stress

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue CL A 201

Chain	Residue
A	ILE129
A	LEU130
A	LYS135

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site_id	AC2
Number of Residues	2
Details	binding site for residue CL A 202

Chain	Residue
A	HIS60
A	ARG69

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site_id	AC3
Number of Residues	6
Details	binding site for residue CL A 203

Chain	Residue
A	TYR169
A	HOH476
A	ALA19
A	LYS20
A	HIS114
A	HIS168

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Functional Information from PROSITE/UniProt

site_id	PS00460
Number of Residues	16
Details	GLUTATHIONE_PEROXID_1 Glutathione peroxidases active site. GFvSIVtNVaSqUGkT

Chain	Residue	Details
A	GLY34-THR49

---

site_id	PS00763
Number of Residues	8
Details	GLUTATHIONE_PEROXID_2 Glutathione peroxidases signature 2. LAFPSNQF

Chain	Residue	Details
A	LEU71-PHE78

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"O70325","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Non-standard residue: {"description":"Selenocysteine","evidences":[{"source":"PubMed","id":"8039723","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9705830","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P36970","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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