PDB: 1001 件ウェブページステータス検索Chemie searchBIRD

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8WA3	Cryo-EM structure of peptide free and Gs-coupled GIPR 分子名称: Gastric inhibitory polypeptide receptor,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,O-antigen polymerase, ... 著者 Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. 登録日 2023-09-06 公開日 2024-03-06 最終更新日 2024-10-16 実験手法 ELECTRON MICROSCOPY (2.86 Å) 主引用文献 Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins. Cell Discov, 10, 2024
8U26	Gaussian Mixture Models based single particle refinement - GPCR (Substance P bound to active human neurokinin 1 receptor in complex with miniGs399 from EMPIAR-10786) 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Chen, M, Pintilie, G. 登録日 2023-09-05 公開日 2023-11-15 最終更新日 2024-10-09 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Improving resolution and resolvability of single-particle cryoEM structures using Gaussian mixture models. Nat.Methods, 21, 2024
8W8Q	Cryo-EM structure of the GPR101-Gs complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Sun, J.P, Gao, N, Yu, X, Wang, G.P, Yang, F, Wang, J.Y, Yang, Z, Guan, Y. 登録日 2023-09-04 公開日 2024-01-03 最終更新日 2024-10-30 実験手法 ELECTRON MICROSCOPY (2.89 Å) 主引用文献 Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nat.Chem.Biol., 20, 2024
8W8R	Cryo-EM structure of the AA-14-bound GPR101-Gs complex 分子名称: 1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Sun, J.P, Yu, X, Gao, N, Yang, F, Wang, J.Y, Yang, Z, Guan, Y, Wang, G.P. 登録日 2023-09-04 公開日 2024-01-03 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nat.Chem.Biol., 20, 2024
8U1U	Structure of a class A GPCR/agonist complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, C-C motif chemokine 1,C-C chemokine receptor type 8,EGFP fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Sun, D, Johnson, M, Masureel, M. 登録日 2023-09-02 公開日 2023-12-20 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8. Nat Commun, 14, 2023
8W88	Cryo-EM structure of the SEP363856-bound TAAR1-Gs complex 分子名称: 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Liu, H, Zheng, Y, Wang, Y, Wang, Y, He, X, Xu, P, Huang, S, Yuan, Q, Zhang, X, Wang, S, Xu, H.E, Xu, F. 登録日 2023-09-01 公開日 2023-11-22 最終更新日 2024-01-03 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature, 624, 2023
8W8B	Cryo-EM structure of SEP-363856 bounded serotonin 1A (5-HT1A) receptor-Gi protein complex 分子名称: 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, Antibody fragment scFv16, CHOLESTEROL, ... 著者 Liu, H, Zheng, Y, Wang, Y, Wang, Y, He, X, Xu, P, Huang, S, Yuan, Q, Zhang, X, Wang, S, Xu, H.E, Xu, F. 登録日 2023-09-01 公開日 2023-11-22 最終更新日 2024-01-03 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature, 624, 2023
8W87	Cryo-EM structure of the METH-TAAR1 complex 分子名称: (2S)-N-methyl-1-phenylpropan-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Liu, H, Zheng, Y, Wang, Y, Wang, Y, He, X, Xu, P, Huang, S, Yuan, Q, Zhang, X, Wang, S, Xu, H.E, Xu, F. 登録日 2023-09-01 公開日 2023-11-22 最終更新日 2024-10-30 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature, 624, 2023
8W8A	Cryo-EM structure of the RO5256390-TAAR1 complex 分子名称: (4S)-4-[(2S)-2-phenylbutyl]-1,3-oxazolidin-2-imine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Liu, H, Zheng, Y, Wang, Y, Wang, Y, He, X, Xu, P, Huang, S, Yuan, Q, Zhang, X, Wang, S, Xu, H.E, Xu, F. 登録日 2023-09-01 公開日 2023-11-22 最終更新日 2024-01-03 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature, 624, 2023
8W89	Cryo-EM structure of the PEA-bound TAAR1-Gs complex 分子名称: 2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Liu, H, Zheng, Y, Wang, Y, Wang, Y, He, X, Xu, P, Huang, S, Yuan, Q, Zhang, X, Wang, S, Xu, H.E, Xu, F. 登録日 2023-09-01 公開日 2023-11-22 最終更新日 2024-11-06 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature, 624, 2023
8U02	CryoEM structure of D2 dopamine receptor in complex with GoA KE mutant and dopamine 分子名称: D(2) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Krumm, B.E, Kapolka, N.J, Fay, J.F, Roth, B.L. 登録日 2023-08-28 公開日 2024-08-21 実験手法 ELECTRON MICROSCOPY (3.28 Å) 主引用文献 A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state. Nat Commun, 15, 2024
8TZQ	CryoEM structure of D2 dopamine receptor in complex with GoA KE Mutant, scFv16, and dopamine 分子名称: D(2) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Krumm, B.E, Kapolka, N.J, Fay, J.F, Roth, B.L. 登録日 2023-08-27 公開日 2024-08-21 最終更新日 2024-11-06 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state. Nat Commun, 15, 2024
8KH5	Cryo-EM structure of the GPR174-Gs complex bound to endogenous lysoPS 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Nie, Y, Qiu, Z, Zheng, S, Chen, S. 登録日 2023-08-21 公開日 2023-10-18 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (2.83 Å) 主引用文献 Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling. Nat Commun, 14, 2023
8KH4	Cryo-EM structure of the GPR161-Gs complex 分子名称: CHOLESTEROL, G-protein coupled receptor 161, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Nie, Y, Qiu, Z, Zheng, S, Chen, S. 登録日 2023-08-21 公開日 2023-10-11 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling. Nat Commun, 14, 2023
8KGG	LPS-bound P2Y10 in complex with G13 分子名称: (2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 He, Y, Yin, Y. 登録日 2023-08-19 公開日 2024-07-31 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (3.06 Å) 主引用文献 Insights into lysophosphatidylserine recognition and G alpha 12/13 -coupling specificity of P2Y10. Cell Chem Biol, 2024
8KGK	Cryo-EM structure of the GPR61-Gs complex 分子名称: G-protein coupled receptor 61, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Nie, Y, Qiu, Z, Zheng, S. 登録日 2023-08-19 公開日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.16 Å) 主引用文献 Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling. Nat Commun, 14, 2023
8KFX	Gi bound CCR8 complex with nonpeptide agonist LMD-009 分子名称: 8-[[3-(2-methoxyphenoxy)phenyl]methyl]-1-(2-phenylethyl)-1,3,8-triazaspiro[4.5]decan-4-one, C-C chemokine receptor type 8,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Jiang, S, Lin, X, Wu, L.J, Xu, F. 登録日 2023-08-16 公開日 2024-02-07 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (2.96 Å) 主引用文献 Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8. Sci Adv, 10, 2024
8KFZ	Gi bound CCR8 in ligand free state 分子名称: C-C chemokine receptor type 8,LgBiT fusion protein,Recombinant Human Rhinovirus, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Jiang, S, Lin, X, Wu, L.J, Xu, F. 登録日 2023-08-16 公開日 2024-02-07 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8. Sci Adv, 10, 2024
8KFY	Gi bound CCR8 complex with nonpeptide agonist ZK 756326 分子名称: 2-[2-[4-[(3-phenoxyphenyl)methyl]piperazin-1-yl]ethoxy]ethanol, C-C chemokine receptor type 8,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Jiang, S, Lin, X, Wu, L.J, Xu, F. 登録日 2023-08-16 公開日 2024-02-07 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (3.06 Å) 主引用文献 Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8. Sci Adv, 10, 2024
8K9L	Full agonist- and positive allosteric modulator-bound mu-type opioid receptor-G protein complex 分子名称: (2~{S})-2-(3-bromanyl-4-methoxy-phenyl)-3-(4-chlorophenyl)sulfonyl-1,3-thiazolidine, DAMGO, G protein subunit alpha i3, ... 著者 Hisano, T, Uchikubo-Kamo, T, Shirouzu, M, Imai, S, Kaneko, S, Shimada, I. 登録日 2023-08-01 公開日 2024-05-29 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3.05 Å) 主引用文献 Structural and dynamic insights into the activation of the mu-opioid receptor by an allosteric modulator. Nat Commun, 15, 2024
8K9K	Full agonist-bound mu-type opioid receptor-G protein complex 分子名称: DAMGO, G protein subunit alpha i3, Guanine nucleotide binding protein, ... 著者 Hisano, T, Uchikubo-Kamo, T, Shirouzu, M, Imai, S, Kaneko, S, Shimada, I. 登録日 2023-08-01 公開日 2024-05-29 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (2.98 Å) 主引用文献 Structural and dynamic insights into the activation of the mu-opioid receptor by an allosteric modulator. Nat Commun, 15, 2024
8K8J	Cannabinoid Receptor 1 bound to Fenofibrate coupling MiniGsq and Nb35 Complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Tang, W.Q, Wang, T.X, Li, F.H, Wang, J.Y. 登録日 2023-07-30 公開日 2024-02-14 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (2.88 Å) 主引用文献 Fenofibrate Recognition and G q Protein Coupling Mechanisms of the Human Cannabinoid Receptor CB1. Adv Sci, 11, 2024
8K6N	Structural complex of neuropeptide Y receptor 2 分子名称: C-flanking peptide of NPY, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Shen, S.Y, Zhao, C, Shao, Z.H. 登録日 2023-07-25 公開日 2024-07-31 最終更新日 2024-11-06 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural complex of neuropeptide Y receptor 2 To Be Published
8K6M	Structural complex of neuropeptide Y receptor 1 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-2, ... 著者 Shen, S.Y, Zhao, C, Shao, Z.H. 登録日 2023-07-25 公開日 2024-07-31 最終更新日 2024-10-16 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural complex of neuropeptide Y receptor 1 To Be Published
8K6O	Structural complex of neuropeptide Y receptor 1 分子名称: C-flanking peptide of NPY, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Shen, S.Y, Zhao, C, Shao, Z.H. 登録日 2023-07-25 公開日 2024-07-31 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural complex of neuropeptide Y receptor 1 To Be Published

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