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2MKB	Structure of NS2(113-137) GBVB protein 分子名称: Protease NS2-3 著者 Montserret, R, Martin, A, Penin, F. 登録日 2014-02-04 公開日 2014-05-07 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 NS2 Proteins of GB Virus B and Hepatitis C Virus Share Common Protease Activities and Membrane Topologies. J.Virol., 88, 2014
2ZJO	Crystal structure of hepatitis C virus NS3 helicase with a novel inhibitor 分子名称: Genome polyprotein, N-[4-(BIS{4-[(3-SULFOPHENYL)AMINO]PHENYL}METHYLENE)CYCLOHEXA-2,5-DIEN-1-YLIDENE]-4-SULFOBENZENAMINIUM 著者 Liaw, S.H, Chen, S.J, Hu, C.Y, Chi, W.K, Chu, I.D, Hwang, L.H, Chern, J.W, Chen, D.S. 登録日 2008-03-07 公開日 2009-03-10 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure-Based Discovery of Triphenylmethane Derivatives as Novel Inhibitors of Hepatitis C Virus Helicase To be Published
5I13	Endonuclease inhibitor 2 bound to influenza strain H1N1 polymerase acidic subunit N-terminal region at pH 7.0 分子名称: 4-{(E)-[2-(4-chlorophenyl)hydrazinylidene]methyl}benzene-1,2,3-triol, MANGANESE (II) ION, Polymerase acidic protein, ... 著者 Fudo, S, Yamamoto, N, Nukaga, M, Odagiri, T, Tashiro, M, Hoshino, T. 登録日 2016-02-05 公開日 2016-02-17 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.151 Å) 主引用文献 Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit Biochemistry, 55, 2016
2LZQ	Structure of NS2(32-57) GBVB protein 分子名称: NS2 peptide 著者 Montserret, R, Penin, F, Martin, A. 登録日 2012-10-08 公開日 2014-04-09 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 NS2 Proteins of GB Virus B and Hepatitis C Virus Share Common Protease Activities and Membrane Topologies. J.Virol., 88, 2014
7A3O	Crystal structure of dengue 1 virus envelope glycoprotein in complex with the scFv fragment of the broadly neutralizing human antibody EDE1 C10 分子名称: Core protein, GLYCEROL, SULFATE ION, ... 著者 Sharma, A, Vaney, M.C, Guardado-Calvo, P, Duquerroy, S, Rouvinski, A, Rey, F.A. 登録日 2020-08-18 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses. Cell, 184, 2021
7A3R	Crystal structure of dengue 1 virus envelope glycoprotein 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Core protein, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Sharma, A, Vaney, M.C, Guardado-Calvo, P, Duquerroy, S, Rouvinski, A, Rey, F.A. 登録日 2020-08-18 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses. Cell, 184, 2021
7A3N	Crystal structure of Zika virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE1 C10 分子名称: CALCIUM ION, Core protein, EDE1 C10 Fab 著者 Sharma, A, Vaney, M.C, Guardado-Calvo, P, Duquerroy, S, Rouvinski, A, Rey, F.A. 登録日 2020-08-18 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses. Cell, 184, 2021
7A3T	Crystal structure of dengue 3 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE1 C8 分子名称: Core protein, EDE1 C8 antibody Fab fragment, GLYCEROL, ... 著者 Sharma, A, Vaney, M.C, Guardado-Calvo, P, Duquerroy, S, Rouvinski, A, Rey, F.A. 登録日 2020-08-18 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses. Cell, 184, 2021
7A3U	Crystal structure of Zika virus envelope glycoprotein in complex with the divalent F(ab')2 fragment of the broadly neutralizing human antibody EDE1 C10 分子名称: EDE1 C10 antibody divalent F(ab')2 fragment, EDE1 C10 divalent F(ab')2 fragment, Envelope protein 著者 Sharma, A, Vaney, M.C, Guardado-Calvo, P, Duquerroy, S, Rouvinski, A, Rey, F.A. 登録日 2020-08-18 公開日 2021-12-08 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses. Cell, 184, 2021
5IEQ	Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-747 1-(4-chlorophenyl)-1H-imidazole 分子名称: 1-(4-CHLOROPHENYL)-1H-IMIDAZOLE, DIMETHYL SULFOXIDE, Polymerase acidic protein 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2016-02-25 公開日 2017-02-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published
5IF2	Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-576 (5,6-dichloro-1H-1,3-benzodiazol-2-yl)methanol 分子名称: (5,6-dichloro-1H-benzimidazol-2-yl)methanol, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2016-02-25 公開日 2017-02-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published
5IFD	Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to follow on fragment EBSI-4721 1-(4-fluorophenyl)-1H-imidazole 分子名称: 1-(4-fluorophenyl)-1H-imidazole, DIMETHYL SULFOXIDE, Polymerase acidic protein 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2016-02-25 公開日 2017-02-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published
5IF5	Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to EBSI-39 (2,3-dichlorophenyl)methanol 分子名称: (2,3-dichlorophenyl)methanol, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2016-02-25 公開日 2017-03-08 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published
1DY9	Inhibition of the Hepatitis C Virus NS3/4A Protease. The Crystal Structures of Two Protease-Inhibitor Complexes (inhibitor I) 分子名称: N-(tert-butoxycarbonyl)-L-alpha-glutamyl-N-[(1R)-1-(carboxycarbonyl)-3,3-difluoropropyl]-L-leucinamide, NONSTRUCTURAL PROTEIN NS4A (P4), PROTEASE/HELICASE NS3 (P70), ... 著者 Di Marco, S, Rizzi, M, Volpari, C, Walsh, M, Narjes, F, Colarusso, S, De Francesco, R, Matassa, V.G, Sollazzo, M. 登録日 2000-01-31 公開日 2001-01-28 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Inhibition of the Hepatitis C Virus Ns3/4A Protease the Crystal Structures of Two Protease-Inhibitor Complexes J.Biol.Chem., 275, 2000
1XCQ	Complex HCV core-Fab 19D9D6-Protein L mutant (D55A,L57H,Y64W) in space group P21 分子名称: Capsid protein C, Monoclonal antibody 19D9D6 Heavy chain, Monoclonal antibody 19D9D6 Light chain, ... 著者 Menez, R, Housden, N.G, Harrison, S, Jolivet-Reynaud, C, Gore, M.G, Stura, E.A. 登録日 2004-09-03 公開日 2005-05-31 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Different crystal packing in Fab-protein L semi-disordered peptide complex. Acta Crystallogr.,Sect.D, 61, 2005
1DY8	Inhibition of the Hepatitis C Virus NS3/4A Protease. The Crystal Structures of Two Protease-Inhibitor Complexes (inhibitor II) 分子名称: N-[(benzyloxy)carbonyl]-L-isoleucyl-N-[(1R)-1-(carboxycarbonyl)-3,3-difluoropropyl]-L-leucinamide, NONSTRUCTURAL PROTEIN NS4A (P4), PROTEASE/HELICASE NS3 (P70) 著者 Di Marco, S, Rizzi, M, Volpari, C, Walsh, M, Narjes, F, Colarusso, S, De Francesco, R, Matassa, V.G, Sollazzo, M. 登録日 2000-01-31 公開日 2001-01-28 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Inhibition of the Hepatitis C Virus Ns3/4A Protease the Crystal Structures of Two Protease-Inhibitor Complexes J.Biol.Chem., 275, 2000
1DXP	Inhibition of the Hepatitis C Virus NS3/4A Protease. The Crystal Structures of Two Protease-Inhibitor Complexes (apo structure) 分子名称: GLYCEROL, NONSTRUCTURAL PROTEIN NS4A (P4), PROTEASE/HELICASE NS3 (P70), ... 著者 Di Marco, S, Rizzi, M, Volpari, C, Walsh, M, Narjes, F, Colarusso, S, De Francesco, R, Matassa, V.G, Sollazzo, M. 登録日 2000-01-13 公開日 2001-01-12 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Inhibition of the Hepatitis C Virus Ns3/4A Protease the Crystal Structures of Two Protease-Inhibitor Complexes J.Biol.Chem., 275, 2000
5IFC	Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to follow on fragment EBSI-4720 1-(4-bromophenyl)-1H-imidazole 分子名称: 1-(4-bromophenyl)-1H-imidazole, DIMETHYL SULFOXIDE, Polymerase acidic protein 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2016-02-25 公開日 2017-02-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published
5IF8	Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-2643 5-[(4-chlorophenyl)methyl]-1,3,4-oxadiazol-2-amine 分子名称: 1,2-ETHANEDIOL, 5-[(4-chlorophenyl)methyl]-1,3,4-oxadiazol-2-amine, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2016-02-25 公開日 2017-02-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published
5IF7	Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-279 N-[(4-chlorophenyl)methyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 分子名称: DIMETHYL SULFOXIDE, N-[(4-chlorophenyl)methyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Polymerase acidic protein 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2016-02-25 公開日 2017-02-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published
1XCT	Complex HCV core-Fab 19D9D6-Protein L mutant (D55A, L57H, Y64W) in space group P21212 分子名称: Capsid protein C, Monoclonal antibody 19D9D6 Heavy chain, Monoclonal antibody 19D9D6 Light chain, ... 著者 Menez, R, Housden, N.G, Harrison, S, Jolivet-Reynaud, C, Gore, M.G, Stura, E.A. 登録日 2004-09-03 公開日 2005-05-31 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Different crystal packing in Fab-protein L semi-disordered peptide complex. Acta Crystallogr.,Sect.D, 61, 2005
1XF5	Complex HCV core-Fab 19D9D6-Protein L mutant (H74C, Y64W)in space group P21212 分子名称: Capsid protein C, Monoclonal antibody 19D9D6 Heavy chain, Monoclonal antibody 19D9D6 Light chain, ... 著者 Menez, R, Housden, N.G, Harrison, S, Jolivet-Reynaud, C, Gore, M.G, Stura, E.A. 登録日 2004-09-14 公開日 2005-05-31 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Different crystal packing in Fab-protein L semi-disordered peptide complex. Acta Crystallogr.,Sect.D, 61, 2005
5JBQ	EF-TU (ESCHERICHIA COLI) IN COMPLEX WITH THIOMURACIN ANALOG 分子名称: Elongation factor Tu 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Palestrant, D, Stams, T. 登録日 2016-04-13 公開日 2016-07-13 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.006 Å) 主引用文献 Antibacterial and Solubility Optimization of Thiomuracin A. J.Med.Chem., 59, 2016
1CU1	CRYSTAL STRUCTURE OF AN ENZYME COMPLEX FROM HEPATITIS C VIRUS 分子名称: PHOSPHATE ION, PROTEIN (PROTEASE/HELICASE NS3), ZINC ION 著者 Yao, N, Weber, P.C. 登録日 1999-08-20 公開日 2000-08-23 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase. Structure Fold.Des., 7, 1999
5IFB	Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to follow on fragment EBSI-4719 5-chloro-2-(1H-imidazol-1-yl)aniline 分子名称: 5-chloro-2-(1H-imidazol-1-yl)aniline, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2016-02-25 公開日 2017-02-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published

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