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7ON1
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BU of 7on1 by Molmil
Cenp-A nucleosome in complex with Cenp-C
分子名称: BJ4_G0006610.mRNA.1.CDS.1, BJ4_G0007000.mRNA.1.CDS.1, DNA (123-MER), ...
著者Yan, K, Yang, J, Zhang, Z, Barford, D.
登録日2021-05-25
公開日2021-07-07
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Cenp-A nucleosome in complex with Cenp-C
To Be Published
8YTI
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BU of 8yti by Molmil
Crystal Structure of Nucleosome-H1x Linker Histone Assembly (sticky-169a DNA fragment)
分子名称: CALCIUM ION, CHLORIDE ION, DNA (169-MER), ...
著者Adhireksan, Z, Qiuye, B, Padavattan, S, Davey, C.A.
登録日2024-03-26
公開日2024-04-03
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Linker Histones Associate Heterogeneously with Nucleosomes in the Condensed State
To Be Published
8GRM
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BU of 8grm by Molmil
Cryo-EM structure of PRC1 bound to H2AK119-UbcH5b-Ub nucleosome
分子名称: COMMD3 protein, DNA (144-MER), DNA (145-MER), ...
著者Ai, H.S, Zebin, T, Zhihend, D, Jiakun, T, Liying, Z, Jia-Bin, L, Man, P, Liu, L.
登録日2022-09-02
公開日2023-04-12
最終更新日2025-06-25
実験手法ELECTRON MICROSCOPY (3.05 Å)
主引用文献Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination.
Chem, 2023
9IPU
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BU of 9ipu by Molmil
cryo-EM structure of the RNF168(1-193)/UbcH5c-Ub ubiquitylation module bound to H1.0-K63-Ub3 modified chromatosome
分子名称: DNA (171-MER), E3 ubiquitin-protein ligase RNF168, Histone H1.0, ...
著者Ai, H.S, Deng, Z.H, Liu, L.
登録日2024-07-11
公開日2024-10-02
最終更新日2025-04-16
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Promotion of RNF168-Mediated Nucleosomal H2A Ubiquitylation by Structurally Defined K63-Polyubiquitylated Linker Histone H1.
Angew.Chem.Int.Ed.Engl., 64, 2025
8W9C
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BU of 8w9c by Molmil
Cryo-EM structure of the Rpd3S complex from budding yeast
分子名称: Chromatin modification-related protein EAF3, Histone deacetylase RPD3, POTASSIUM ION, ...
著者Wang, C, Zhan, X.
登録日2023-09-05
公開日2024-05-15
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structures and dynamics of Rpd3S complex bound to nucleosome.
Sci Adv, 10, 2024
3G86
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BU of 3g86 by Molmil
Hepatitis C virus polymerase NS5B (BK 1-570) with thiazine inhibitor
分子名称: N-{3-[6-fluoro-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxido-4H-1,4-benzothiazin-7-yl}methanesulfonamide, NICKEL (II) ION, RNA-directed RNA polymerase
著者Harris, S.F, Ghate, M.
登録日2009-02-11
公開日2009-09-08
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones
Bioorg.Med.Chem.Lett., 19, 2009
6W4S
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BU of 6w4s by Molmil
Structure of apo human ferroportin in lipid nanodisc
分子名称: Fab45D8 Heavy Chain, Fab45D8 Light Chain, Solute carrier family 40 member 1
著者Billesboelle, C.B, Azumaya, C.M, Gonen, S, Powers, A, Kretsch, R.C, Schneider, S, Arvedson, T, Dror, R.O, Cheng, Y, Manglik, A.
登録日2020-03-11
公開日2020-09-09
最終更新日2025-05-14
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms.
Nature, 586, 2020
6WBV
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BU of 6wbv by Molmil
Structure of human ferroportin bound to hepcidin and cobalt in lipid nanodisc
分子名称: (1S)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTANOYLOXY)METHYL]ETHYL OCTANOATE, COBALT (II) ION, Fab45D8 Heavy Chain, ...
著者Billesboelle, C.B, Azumaya, C.M, Gonen, S, Powers, A, Kretsch, R.C, Schneider, S, Arvedson, T, Dror, R.O, Cheng, Y, Manglik, A.
登録日2020-03-27
公開日2020-09-09
最終更新日2025-05-28
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms.
Nature, 586, 2020
5CIY
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BU of 5ciy by Molmil
Structural basis of the recognition of H3K36me3 by DNMT3B PWWP domain
分子名称: DNA (5'-D(P*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*(3DR)P*GP*CP*AP*TP*GP*G)-3'), Modification methylase HhaI, ...
著者Rondelet, G, DAL MASO, T, Willems, L, Wouters, J.
登録日2015-07-13
公開日2016-03-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.594 Å)
主引用文献Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B.
J.Struct.Biol., 194, 2016
3U17
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BU of 3u17 by Molmil
Structure of BasE N-terminal domain from Acinetobacter baumannii bound to 6-(p-benzoyl)phenyl-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 6-(4-benzoylphenyl)-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid, ...
著者Gulick, A.M, Drake, E.J, Aldrich, C.C, Neres, J.
登録日2011-09-29
公開日2012-10-03
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Non-nucleoside inhibitors of BasE, an adenylating enzyme in the siderophore biosynthetic pathway of the opportunistic pathogen Acinetobacter baumannii.
J.Med.Chem., 56, 2013
3H5S
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BU of 3h5s by Molmil
Hepatitis C virus polymerase NS5B with saccharin inhibitor
分子名称: (5S)-5-tert-butyl-1-(4-fluoro-3-methylbenzyl)-4-hydroxy-3-[8-(methylsulfonyl)-1,1-dioxido-6,7,8,9-tetrahydroisothiazolo[4,5-h]isoquinolin-3-yl]-1,5-dihydro-2H-pyrrol-2-one, RNA-directed RNA polymerase
著者Harris, S.F, Wong, A.
登録日2009-04-22
公開日2009-09-08
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides
Bioorg.Med.Chem.Lett., 19, 2009
1YUY
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BU of 1yuy by Molmil
HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE GENOTYPE 2a
分子名称: RNA-Dependent RNA polymerase, SULFATE ION
著者Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G.
登録日2005-02-14
公開日2005-03-22
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
J.Biol.Chem., 280, 2005
3H5U
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BU of 3h5u by Molmil
Hepatitis C virus polymerase NS5B with saccharin inhibitor 1
分子名称: N-({3-[(5S)-5-tert-butyl-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxido-1,2-benzisothiazol-7-yl}methyl)methanesulfonamide, RNA-directed RNA polymerase
著者Harris, S.F, Ghate, M.
登録日2009-04-22
公開日2009-09-08
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides
Bioorg.Med.Chem.Lett., 19, 2009
6KBB
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BU of 6kbb by Molmil
Role of the DEF/Y motif of Swc5 in histone H2A.Z deposition
分子名称: Histone H2A type 1-D, Histone H2B type 2-E, SWR1-complex protein 5
著者Huang, Y, Zhou, Z.
登録日2019-06-24
公開日2020-01-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.365 Å)
主引用文献Role of a DEF/Y motif in histone H2A-H2B recognition and nucleosome editing.
Proc.Natl.Acad.Sci.USA, 117, 2020
1YV2
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BU of 1yv2 by Molmil
Hepatitis C virus NS5B RNA-dependent RNA Polymerase genotype 2a
分子名称: GLYCEROL, RNA dependent RNA polymerase, SULFATE ION
著者Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G.
登録日2005-02-14
公開日2005-03-22
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors
J.Biol.Chem., 280, 2005
3U16
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BU of 3u16 by Molmil
Structure of BasE N-terminal domain from Acinetobacter baumannii bound to 6-(p-benzyloxy)phenyl-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid.
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 6-[4-(benzyloxy)phenyl]-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid, ...
著者Gulick, A.M, Drake, E.J, Aldrich, C.C, Neres, J.
登録日2011-09-29
公開日2012-10-03
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Non-nucleoside inhibitors of BasE, an adenylating enzyme in the siderophore biosynthetic pathway of the opportunistic pathogen Acinetobacter baumannii.
J.Med.Chem., 56, 2013
5CIU
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BU of 5ciu by Molmil
Structural basis of the recognition of H3K36me3 by DNMT3B PWWP domain
分子名称: DNA (cytosine-5)-methyltransferase 3B, GLYCEROL, Histone H3.2
著者Rondelet, G, DAL MASO, T, Willems, L, Wouters, J.
登録日2015-07-13
公開日2016-03-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B.
J.Struct.Biol., 194, 2016
2AX1
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BU of 2ax1 by Molmil
Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5ee)
分子名称: 5R-(3,4-DICHLOROPHENYLMETHYL)-3-(2-THIOPHENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE, Genome polyprotein, SULFATE ION
著者Powers, J.P, Piper, D.E, Li, Y, Mayorga, V, Anzola, J, Chen, J.M, Jaen, J.C, Lee, G, Liu, J, Peterson, M.G, Tonn, G.R, Ye, Q, Walker, N.P, Wang, Z.
登録日2005-09-02
公開日2006-01-24
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase.
J.Med.Chem., 49, 2006
8RHN
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BU of 8rhn by Molmil
Structure of the 55LCC ATPase complex
分子名称: ATPase family gene 2 protein homolog A, ATPase family gene 2 protein homolog B, Cyclin-dependent kinase 2-interacting protein, ...
著者Foglizzo, M, Degtjarik, O, Zeqiraj, E.
登録日2023-12-15
公開日2024-03-27
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity.
Cell, 187, 2024
4LJY
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BU of 4ljy by Molmil
Crystal structure of RNA splicing effector Prp5 in complex with ADP
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Zhang, Z.-M, Li, J, Yang, F, Xu, Y, Zhou, J.
登録日2013-07-05
公開日2013-12-11
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly.
Cell Rep, 5, 2013
4LGE
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BU of 4lge by Molmil
Crystal structure of clAP1 BIR3 bound to T3261256
分子名称: (4S,6aR,7aS)-5-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(4R)-3,4-dihydro-2H-chromen-4-yl]octahydro-1H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazine-4-carboxamide, Baculoviral IAP repeat-containing protein 2, ZINC ION
著者Dougan, D.R.
登録日2013-06-27
公開日2013-08-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists.
Bioorg.Med.Chem., 21, 2013
4LK2
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BU of 4lk2 by Molmil
Crystal structure of RNA splicing effector Prp5
分子名称: NICKEL (II) ION, Pre-mRNA-processing ATP-dependent RNA helicase PRP5
著者Zhang, Z.-M, Li, J, Yang, F, Xu, Y, Zhou, J.
登録日2013-07-05
公開日2013-12-11
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly.
Cell Rep, 5, 2013
4LGU
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BU of 4lgu by Molmil
Crystal structure of clAP1 BIR3 bound to T3226692
分子名称: (3S,8aR)-N-((R)-chroman-4-yl)-2-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)octahydropyrrolo[1,2-a]pyrazine-3-carboxamide, Baculoviral IAP repeat-containing protein 2, ZINC ION
著者Dougan, D.R, Mol, C.D, Snell, G.P.
登録日2013-06-28
公開日2013-08-28
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists.
Bioorg.Med.Chem., 21, 2013
7CRO
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BU of 7cro by Molmil
NSD2 bearing E1099K/T1150A dual mutation in complex with 187-bp NCP
分子名称: DNA (168-MER), Histone H2A, Histone H2B, ...
著者Li, W, Tian, W, Yuan, G, Deng, P, Gozani, O, Patel, D, Wang, Z.
登録日2020-08-14
公開日2020-10-21
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.75 Å)
主引用文献Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.
Nature, 590, 2021
6R87
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BU of 6r87 by Molmil
Yeast Vms1 (Q295L)-60S ribosomal subunit complex (pre-state without Arb1)
分子名称: 25S rRNA, 5.8S rRNA, 5S rRNA, ...
著者Su, T, Izawa, T, Cheng, J, Yamashita, Y, Berninghausen, O, Inada, T, Neupert, W, Beckmann, R.
登録日2019-03-31
公開日2019-06-26
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.
Nature, 570, 2019

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件を2025-07-09に公開中

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