4LGU
Crystal structure of clAP1 BIR3 bound to T3226692
Summary for 4LGU
Entry DOI | 10.2210/pdb4lgu/pdb |
Related | 4LGE |
Related PRD ID | PRD_001141 |
Descriptor | Baculoviral IAP repeat-containing protein 2, ZINC ION, (3S,8aR)-N-((R)-chroman-4-yl)-2-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)octahydropyrrolo[1,2-a]pyrazine-3-carboxamide, ... (4 entities in total) |
Functional Keywords | lap family, 3 bir repeats, card domain, 1 ring-type zinc finger, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q13490 |
Total number of polymer chains | 2 |
Total formula weight | 27771.84 |
Authors | Dougan, D.R.,Mol, C.D.,Snell, G.P. (deposition date: 2013-06-28, release date: 2013-08-28, Last modification date: 2024-05-22) |
Primary citation | Asano, M.,Hashimoto, K.,Saito, B.,Shiokawa, Z.,Sumi, H.,Yabuki, M.,Yoshimatsu, M.,Aoyama, K.,Hamada, T.,Morishita, N.,Dougan, D.R.,Mol, C.D.,Yoshida, S.,Ishikawa, T. Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists. Bioorg.Med.Chem., 21:5725-5737, 2013 Cited by PubMed: 23928071DOI: 10.1016/j.bmc.2013.07.020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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