1T79
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![BU of 1t79 by Molmil](/molmil-images/mine/1t79) | Crystal structure of the androgen receptor ligand binding domain in complex with a FxxLW motif | 分子名称: | 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, FxxLW motif peptide | 著者 | Hur, E, Pfaff, S.J, Payne, E.S, Gron, H, Buehrer, B.M, Fletterick, R.J. | 登録日 | 2004-05-08 | 公開日 | 2004-08-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Recognition and accommodation at the androgen receptor coactivator binding interface. Plos Biol., 2, 2004
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5E54
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![BU of 5e54 by Molmil](/molmil-images/mine/5e54) | Two apo structures of the adenine riboswitch aptamer domain determined using an X-ray free electron laser | 分子名称: | MAGNESIUM ION, Vibrio vulnificus strain 93U204 chromosome II, adenine riboswitch aptamer domain | 著者 | Stagno, J.R, Wang, Y.-X, Liu, Y, Bhandari, Y.R, Conrad, C.E, Nelson, G, Li, C, Wendel, D.R, White, T.A, Barty, A, Tuckey, R.A, Zatsepin, N.A, Grant, T.D, Fromme, P, Tan, K, Ji, X, Spence, J.C.H. | 登録日 | 2015-10-07 | 公開日 | 2016-11-23 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography. Nature, 541, 2017
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4N5B
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![BU of 4n5b by Molmil](/molmil-images/mine/4n5b) | Crystal structure of the Nipah virus phosphoprotein tetramerization domain | 分子名称: | IMIDAZOLE, Phosphoprotein | 著者 | Bruhn, J.F, Barnett, K, Bibby, J, Thomas, J, Keegan, R, Rigden, D, Bornholdt, Z.A, Saphire, E.O. | 登録日 | 2013-10-09 | 公開日 | 2013-11-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of the nipah virus phosphoprotein tetramerization domain. J.Virol., 88, 2014
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1KYQ
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![BU of 1kyq by Molmil](/molmil-images/mine/1kyq) | Met8p: A bifunctional NAD-dependent dehydrogenase and ferrochelatase involved in siroheme synthesis. | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Siroheme biosynthesis protein MET8 | 著者 | Schubert, H.L, Raux, E, Brindley, A.A, Wilson, K.S, Hill, C.P, Warren, M.J. | 登録日 | 2002-02-05 | 公開日 | 2002-05-08 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase. EMBO J., 21, 2002
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3PEA
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![BU of 3pea by Molmil](/molmil-images/mine/3pea) | Crystal structure of enoyl-CoA hydratase from Bacillus anthracis str. 'Ames Ancestor' | 分子名称: | ACETATE ION, CITRATE ANION, Enoyl-CoA hydratase/isomerase family protein, ... | 著者 | Filippova, E.V, Wawrzak, Z, Kudritska, M, Edwards, A, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2010-10-25 | 公開日 | 2010-11-03 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.817 Å) | 主引用文献 | Crystal structure of enoyl-CoA hydratase from Bacillus anthracis str. 'Ames Ancestor' To be Published
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1HYO
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![BU of 1hyo by Molmil](/molmil-images/mine/1hyo) | CRYSTAL STRUCTURE OF FUMARYLACETOACETATE HYDROLASE COMPLEXED WITH 4-(HYDROXYMETHYLPHOSPHINOYL)-3-OXO-BUTANOIC ACID | 分子名称: | 4-[HYDROXY-[METHYL-PHOSPHINOYL]]-3-OXO-BUTANOIC ACID, ACETATE ION, CALCIUM ION, ... | 著者 | Bateman, R.L, Bhanumoorthy, P, Witte, J.F, McClard, R.W, Grompe, M, Timm, D.E. | 登録日 | 2001-01-21 | 公開日 | 2001-02-14 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Mechanistic inferences from the crystal structure of fumarylacetoacetate hydrolase with a bound phosphorus-based inhibitor. J.Biol.Chem., 276, 2001
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7M4U
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![BU of 7m4u by Molmil](/molmil-images/mine/7m4u) | A. baumannii Ribosome-Eravacycline complex: 30S | 分子名称: | 16s Ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | 著者 | Morgan, C.E, Yu, E.W. | 登録日 | 2021-03-22 | 公開日 | 2021-05-19 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | 主引用文献 | Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii. Mbio, 12, 2021
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7M4X
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1L5S
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![BU of 1l5s by Molmil](/molmil-images/mine/1l5s) | Human liver glycogen phosphorylase complexed with uric acid, N-Acetyl-beta-D-glucopyranosylamine, and CP-403,700 | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, Glycogen phosphorylase, liver form, ... | 著者 | Ekstrom, J.L, Pauly, T.A, Carty, M.D, Soeller, W.C, Culp, J, Danley, D.E, Hoover, D.J, Treadway, J.L, Gibbs, E.M, Fletterick, R.J, Day, Y.S.N, Myszka, D.G, Rath, V.L. | 登録日 | 2002-03-07 | 公開日 | 2002-12-04 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-activity analysis of the purine binding
site of human liver glycogen phosphorylase. Chem.Biol., 9, 2002
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1HZ5
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![BU of 1hz5 by Molmil](/molmil-images/mine/1hz5) | CRYSTAL STRUCTURES OF THE B1 DOMAIN OF PROTEIN L FROM PEPTOSTREPTOCOCCUS MAGNUS, WITH A TYROSINE TO TRYPTOPHAN SUBSTITUTION | 分子名称: | PROTEIN L, ZINC ION | 著者 | O'Neill, J.W, Kim, D.E, Baker, D, Zhang, K.Y.J. | 登録日 | 2001-01-23 | 公開日 | 2001-04-04 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structures of the B1 domain of protein L from Peptostreptococcus magnus with a tyrosine to tryptophan substitution. Acta Crystallogr.,Sect.D, 57, 2001
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228L
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![BU of 228l by Molmil](/molmil-images/mine/228l) | GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME | 著者 | Baldwin, E.P, Baase, W.A, Zhang, X.-J, Feher, V, Matthews, B.W. | 登録日 | 1997-06-25 | 公開日 | 1998-03-18 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Generation of ligand binding sites in T4 lysozyme by deficiency-creating substitutions. J.Mol.Biol., 277, 1998
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4A0K
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![BU of 4a0k by Molmil](/molmil-images/mine/4a0k) | STRUCTURE OF DDB1-DDB2-CUL4A-RBX1 BOUND TO A 12 BP ABASIC SITE CONTAINING DNA-DUPLEX | 分子名称: | 12 BP DNA, 12 BP THF CONTAINING DNA, CULLIN-4A, ... | 著者 | Fischer, E.S, Scrima, A, Gut, H, Thoma, N.H. | 登録日 | 2011-09-09 | 公開日 | 2011-12-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (5.93 Å) | 主引用文献 | The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation. Cell(Cambridge,Mass.), 147, 2011
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6CL2
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3NIX
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![BU of 3nix by Molmil](/molmil-images/mine/3nix) | Crystal structure of flavoprotein/dehydrogenase from Cytophaga hutchinsonii. Northeast Structural Genomics Consortium Target ChR43. | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Flavoprotein/dehydrogenase | 著者 | Vorobiev, S, Su, M, Seetharaman, J, Sahdev, S, Xiao, R, Foote, E.L, Ciccosanti, C, Maglaqui, M, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2010-06-16 | 公開日 | 2010-06-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of flavoprotein/dehydrogenase from Cytophaga hutchinsonii. To be Published
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6H3O
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![BU of 6h3o by Molmil](/molmil-images/mine/6h3o) | Alcohol oxidase from Phanerochaete chrysosporium mutant F101S | 分子名称: | Alcohol oxidase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL | 著者 | Nguyen, Q.-T, Romero, E, Dijkman, W.P, de Vasconcellos, S.P, Binda, C, Mattevi, A, Fraaije, M.W. | 登録日 | 2018-07-19 | 公開日 | 2018-10-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure-Based Engineering of Phanerochaete chrysosporium Alcohol Oxidase for Enhanced Oxidative Power toward Glycerol. Biochemistry, 57, 2018
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3L2P
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![BU of 3l2p by Molmil](/molmil-images/mine/3l2p) | Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching Between Two DNA Bound States | 分子名称: | 5'-D(*GP*CP*CP*AP*GP*TP*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*CP*CP*G)-3', 5'-D(*GP*TP*CP*GP*GP*AP*CP*TP*G)-3', 5'-D(P*CP*GP*GP*GP*AP*TP*GP*CP*GP*TP*C)-3', ... | 著者 | Cotner-Gohara, E.A, Kim, I.K, Hammel, M, Tainer, J.A, Tomkinson, A, Ellenberger, T. | 登録日 | 2009-12-15 | 公開日 | 2010-07-14 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching between Two DNA-Bound States. Biochemistry, 49, 2010
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6MUP
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2OC8
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![BU of 2oc8 by Molmil](/molmil-images/mine/2oc8) | Structure of Hepatitis C Viral NS3 protease domain complexed with NS4A peptide and ketoamide SCH503034 | 分子名称: | BETA-MERCAPTOETHANOL, Hepatitis C virus, ZINC ION, ... | 著者 | Prongay, A.J, Guo, Z, Yao, N, Fischmann, T, Strickland, C, Myers, J, Weber, P.C, Malcolm, B, Beyer, B.M, Ingram, R, Pichardo, J, Hong, Z, Prosise, W.W, Ramanathan, L, Taremi, S.S, Yarosh-Tomaine, T, Zhang, R, Senior, M, Yang, R.S, Arasappan, A, Bennett, F, Bogen, S.L, Chen, K, Jao, E, Liu, Y.T, Lovey, R.G, Saksena, A.K, Venkatraman, S, Girijavallabhan, V, Njoroge, F.G, Madison, V. | 登録日 | 2006-12-20 | 公開日 | 2007-07-31 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization. J.Med.Chem., 50, 2007
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6D1Y
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![BU of 6d1y by Molmil](/molmil-images/mine/6d1y) | Crystal structure of Tyrosine-protein kinase receptor in complex with 2,4-dichloro-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)benzamide Inhibitor | 分子名称: | 2,4-dichloro-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)benzamide, High affinity nerve growth factor receptor | 著者 | Greasley, S.E, Johnson, E, Kraus, M.L, Cronin, C.N. | 登録日 | 2018-04-12 | 公開日 | 2018-05-02 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors. J. Med. Chem., 62, 2019
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3H1H
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![BU of 3h1h by Molmil](/molmil-images/mine/3h1h) | Cytochrome bc1 complex from chicken | 分子名称: | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, CARDIOLIPIN, CYTOCHROME C1, ... | 著者 | Zhang, Z, Huang, L, Shulmeister, V.M, Chi, Y.I, Kim, K.K, Hung, L.W, Crofts, A.R, Berry, E.A, Kim, S.H. | 登録日 | 2009-04-12 | 公開日 | 2009-04-28 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.16 Å) | 主引用文献 | Electron Transfer by Domain Movement in Cytochrome Bc1 Nature, 392, 1998
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2OCV
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![BU of 2ocv by Molmil](/molmil-images/mine/2ocv) | Structural basis of Na+ activation mimicry in murine thrombin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombin | 著者 | Marino, F, Chen, Z, Ergenekan, C.E, Bush, L.A, Mathews, F.S, Di Cera, E. | 登録日 | 2006-12-21 | 公開日 | 2007-04-10 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis of na+ activation mimicry in murine thrombin. J.Biol.Chem., 282, 2007
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6MZO
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3NG9
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![BU of 3ng9 by Molmil](/molmil-images/mine/3ng9) | Structure to Function Correlations for Adeno-associated Virus Serotype 1 | 分子名称: | 6-AMINOPYRIMIDIN-2(1H)-ONE, ADENINE, Capsid protein | 著者 | Govindasamy, L, Miller, E.B, Gurda, B, McKenna, R, Zolotukhin, S, Muzyczka, N, Agbandje-McKenna, M. | 登録日 | 2010-06-11 | 公開日 | 2011-12-21 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure to Function Correlations for Adeno-Associated Virus serotype 1 To be Published
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3NJO
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![BU of 3njo by Molmil](/molmil-images/mine/3njo) | X-ray crystal structure of the Pyr1-pyrabactin A complex | 分子名称: | 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, Abscisic acid receptor PYR1, CHLORIDE ION, ... | 著者 | Burgie, E.S, Bingman, C.A, Phillips Jr, G.N, Peterson, F.C, Volkman, B.F, Cutler, S.R, Jensen, D.R, Center for Eukaryotic Structural Genomics (CESG) | 登録日 | 2010-06-17 | 公開日 | 2010-08-18 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.473 Å) | 主引用文献 | Structural basis for selective activation of ABA receptors. Nat.Struct.Mol.Biol., 17, 2010
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6GL8
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![BU of 6gl8 by Molmil](/molmil-images/mine/6gl8) | Crystal structure of Bcl-2 in complex with the novel orally active inhibitor S55746 | 分子名称: | Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2, ~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide | 著者 | Casara, P, Davidson, J, Claperon, A, Le Toumelin-Braizat, G, Vogler, M, Bruno, A, Chanrion, M, Lysiak-Auvity, G, Le Diguarher, T, Starck, J.B, Chen, I, Whitehead, N, Graham, C, Matassova, N, Dokurno, P, Pedder, C, Wang, Y, Qiu, S, Girard, A.M, Schneider, E, Grave, F, Studeny, A, Guasconi, G, Rocchetti, F, Maiga, S, Henlin, J.M, Colland, F, Kraus-Berthier, L, Le Gouill, S, Dyer, M.J.S, Hubbard, R, Wood, M, Amiot, M, Cohen, G.M, Hickman, J.A, Morris, E, Murray, J, Geneste, O. | 登録日 | 2018-05-23 | 公開日 | 2018-11-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth. Oncotarget, 9, 2018
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