6GL8
Crystal structure of Bcl-2 in complex with the novel orally active inhibitor S55746
Summary for 6GL8
Entry DOI | 10.2210/pdb6gl8/pdb |
Descriptor | Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2, ~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide (3 entities in total) |
Functional Keywords | apoptosis-inhibitor complex, bcl-2, bh3-mimetics, apoptosis |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 20947.37 |
Authors | Casara, P.,Davidson, J.,Claperon, A.,Le Toumelin-Braizat, G.,Vogler, M.,Bruno, A.,Chanrion, M.,Lysiak-Auvity, G.,Le Diguarher, T.,Starck, J.B.,Chen, I.,Whitehead, N.,Graham, C.,Matassova, N.,Dokurno, P.,Pedder, C.,Wang, Y.,Qiu, S.,Girard, A.M.,Schneider, E.,Grave, F.,Studeny, A.,Guasconi, G.,Rocchetti, F.,Maiga, S.,Henlin, J.M.,Colland, F.,Kraus-Berthier, L.,Le Gouill, S.,Dyer, M.J.S.,Hubbard, R.,Wood, M.,Amiot, M.,Cohen, G.M.,Hickman, J.A.,Morris, E.,Murray, J.,Geneste, O. (deposition date: 2018-05-23, release date: 2018-11-07, Last modification date: 2024-01-17) |
Primary citation | Casara, P.,Davidson, J.,Claperon, A.,Le Toumelin-Braizat, G.,Vogler, M.,Bruno, A.,Chanrion, M.,Lysiak-Auvity, G.,Le Diguarher, T.,Starck, J.B.,Chen, I.,Whitehead, N.,Graham, C.,Matassova, N.,Dokurno, P.,Pedder, C.,Wang, Y.,Qiu, S.,Girard, A.M.,Schneider, E.,Grave, F.,Studeny, A.,Guasconi, G.,Rocchetti, F.,Maiga, S.,Henlin, J.M.,Colland, F.,Kraus-Berthier, L.,Le Gouill, S.,Dyer, M.J.S.,Hubbard, R.,Wood, M.,Amiot, M.,Cohen, G.M.,Hickman, J.A.,Morris, E.,Murray, J.,Geneste, O. S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth. Oncotarget, 9:20075-20088, 2018 Cited by PubMed: 29732004DOI: 10.18632/oncotarget.24744 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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