6GL8

Crystal structure of Bcl-2 in complex with the novel orally active inhibitor S55746

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042981	biological_process	regulation of apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue F3Q A 301

Chain	Residue
A	PHE104
A	PHE153
A	ASP171
A	HOH415
A	HOH421
A	HOH431
A	HOH482
A	HOH484
A	HOH489
A	HOH525
A	TYR108
A	ASP111
A	PHE112
A	GLN118
A	LEU137
A	GLY145
A	ARG146
A	ALA149

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Functional Information from PROSITE/UniProt

site_id	PS01080
Number of Residues	19
Details	BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFeFGG

Chain	Residue	Details
A	LEU137-GLY155

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site_id	PS01258
Number of Residues	12
Details	BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdnGGWDaFV

Chain	Residue	Details
A	TRP188-VAL199

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site_id	PS01259
Number of Residues	15
Details	BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VhktLReAGDDFSRR

Chain	Residue	Details
A	VAL93-ARG107

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site_id	PS01260
Number of Residues	21
Details	BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DNREIVmKYIHYKLSQRGYeW

Chain	Residue	Details
A	ASP10-TRP30

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by MAPK8 => ECO:0000269|PubMed:18570871

Chain	Residue	Details
A	LYS95

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by MAPK8 and PKC => ECO:0000269|PubMed:18570871

Chain	Residue	Details
A	THR96

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by MAPK8 => ECO:0000269|PubMed:18570871

Chain	Residue	Details
A	ALA113

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