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6GL8

Crystal structure of Bcl-2 in complex with the novel orally active inhibitor S55746

Functional Information from GO Data
ChainGOidnamespacecontents
A0042981biological_processregulation of apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue F3Q A 301
ChainResidue
APHE104
APHE153
AASP171
AHOH415
AHOH421
AHOH431
AHOH482
AHOH484
AHOH489
AHOH525
ATYR108
AASP111
APHE112
AGLN118
ALEU137
AGLY145
AARG146
AALA149

Functional Information from PROSITE/UniProt
site_idPS01080
Number of Residues19
DetailsBH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFeFGG
ChainResidueDetails
ALEU137-GLY155

site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdnGGWDaFV
ChainResidueDetails
ATRP188-VAL199

site_idPS01259
Number of Residues15
DetailsBH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VhktLReAGDDFSRR
ChainResidueDetails
AVAL93-ARG107

site_idPS01260
Number of Residues21
DetailsBH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DNREIVmKYIHYKLSQRGYeW
ChainResidueDetails
AASP10-TRP30

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues15
DetailsRegion: {"description":"Required for interaction with SEPTIN4 isoform ARTS. Required XIAP-mediated ubiquitination and apoptosis","evidences":[{"source":"PubMed","id":"29020630","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues20
DetailsMotif: {"description":"BH4"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues14
DetailsMotif: {"description":"BH3"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues19
DetailsMotif: {"description":"BH1"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues15
DetailsMotif: {"description":"BH2"}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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