6D1Y
Crystal structure of Tyrosine-protein kinase receptor in complex with 2,4-dichloro-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)benzamide Inhibitor
Summary for 6D1Y
Entry DOI | 10.2210/pdb6d1y/pdb |
Descriptor | High affinity nerve growth factor receptor, 2,4-dichloro-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)benzamide (3 entities in total) |
Functional Keywords | allostric inhibitor tyrosine kinase, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 36456.72 |
Authors | Greasley, S.E.,Johnson, E.,Kraus, M.L.,Cronin, C.N. (deposition date: 2018-04-12, release date: 2018-05-02, Last modification date: 2024-03-13) |
Primary citation | Bagal, S.K.,Omoto, K.,Blakemore, D.C.,Bungay, P.J.,Bilsland, J.G.,Clarke, P.J.,Corbett, M.S.,Cronin, C.N.,Cui, J.J.,Dias, R.,Flanagan, N.J.,Greasley, S.E.,Grimley, R.,Johnson, E.,Fengas, D.,Kitching, L.,Kraus, M.L.,McAlpine, I.,Nagata, A.,Waldron, G.J.,Warmus, J.S. Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors. J. Med. Chem., 62:247-265, 2019 Cited by PubMed: 29672039DOI: 10.1021/acs.jmedchem.8b00280 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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