6D1Y
Crystal structure of Tyrosine-protein kinase receptor in complex with 2,4-dichloro-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)benzamide Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | High affinity nerve growth factor receptor | polymer | 320 | 36110.5 | 1 | UniProt (P04629) Pfam (PF07714) | Homo sapiens (Human) | Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA |
| 2 | B (A) | 2,4-dichloro-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)benzamide | non-polymer | 346.2 | 1 | Chemie (FQJ) | |||
| 3 | C (A) | water | water | 18.0 | 154 | Chemie (HOH) |
Sequence modifications
A: 479 - 796 (UniProt: P04629)
| PDB | External Database | Details |
|---|---|---|
| Gly 477 | - | expression tag |
| Ser 478 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36110.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 346.2 | |
| All* | Total formula weight | 36456.7 |
