PDB: 437 件ウェブページステータス検索Chemie searchBIRD

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6B3Q	Cryo-EM structure of human insulin degrading enzyme in complex with insulin 分子名称: Insulin, Insulin-degrading enzyme 著者 Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. 登録日 2017-09-22 公開日 2017-11-22 最終更新日 2021-04-28 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
5WBT	Solution Structure and Dynamics of an Ultra-Stable Single-Chain Insulin Analog STUDIES OF AN ENGINEERED MONOMER AND IMPLICATIONS FOR RECEPTOR BINDING 分子名称: Insulin 著者 Glidden, M.D, Yang, Y, Wickramasinghe, N.P, Weiss, M.A. 登録日 2017-06-29 公開日 2017-11-15 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding. J. Biol. Chem., 293, 2018
5WDM	An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein 分子名称: Single-chain insulin analog 著者 Yee, V.C, Aldabbagh, K, Peng, Y. 登録日 2017-07-05 公開日 2017-11-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.803 Å) 主引用文献 An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein. J. Biol. Chem., 293, 2018
5VIZ	X-Ray structure of Insulin Glargine 分子名称: Insulin, chain alpha, chain beta 著者 Reyes-Grajeda, J.P, Romero, A. 登録日 2017-04-17 公開日 2017-10-18 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 X-Ray structure of Insulin Glargine To Be Published
5MHD	Biosynthetic engineered A22S-B3K-B31R human insulin monomer structure in water/acetonitrile solutions. 分子名称: Insulin 著者 Bocian, W, Kozerski, L, Bednarek, E, Sitkowski, J. 登録日 2016-11-24 公開日 2017-08-09 最終更新日 2019-05-08 実験手法 SOLUTION NMR 主引用文献 Structure and pharmaceutical formulation development of a new long-acting recombinant human insulin analog studied by NMR and MS. J Pharm Biomed Anal, 135, 2017
5KQV	Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, Insulin receptor,Insulin receptor, ... 著者 Lawrence, M.C, Smith, B.J, Croll, T.I. 登録日 2016-07-06 公開日 2017-07-19 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.4 Å) 主引用文献 How insulin engages its primary binding site on the insulin receptor. Nature, 493, 2013
5AZZ	Crystal structure of seleno-insulin 分子名称: Insulin A chain, Insulin B chain 著者 Watanabe, S, Okumura, M, Arai, K, Takei, T, Asahina, Y, Hojo, H, Iwaoka, M, Inaba, K. 登録日 2015-10-23 公開日 2017-05-03 最終更新日 2017-06-14 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Preparation of Selenoinsulin as a Long-Lasting Insulin Analogue. Angew. Chem. Int. Ed. Engl., 56, 2017
5MT3	Human insulin in complex with serotonin and arginine 分子名称: ARGININE, CHLORIDE ION, Insulin, ... 著者 Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. 登録日 2017-01-06 公開日 2017-04-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules. J. Biol. Chem., 292, 2017
5MT9	Human insulin in complex with serotonin and arginine 分子名称: ARGININE, CHLORIDE ION, Insulin, ... 著者 Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. 登録日 2017-01-07 公開日 2017-04-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules. J. Biol. Chem., 292, 2017
5MAM	Human insulin in complex with serotonin 分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ... 著者 Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. 登録日 2016-11-03 公開日 2017-04-05 最終更新日 2017-05-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules. J. Biol. Chem., 292, 2017
5MIZ	MD ensemble of bovine insulin 分子名称: Insulin 著者 Efimov, S.V, Zgadzay, Y.O, Klochkov, V.V. 登録日 2016-11-29 公開日 2017-01-25 最終更新日 2019-05-08 実験手法 SOLUTION NMR 主引用文献 MD ensemble of bovine insulin To Be Published
5HPR	Insulin with proline analog HyP at position B28 in the T2 state 分子名称: GLYCEROL, Insulin A-Chain, Insulin B-Chain, ... 著者 Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A. 登録日 2016-01-21 公開日 2017-01-25 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation. J. Am. Chem. Soc., 139, 2017
5HQI	Insulin with proline analog HzP at position B28 in the T2 state 分子名称: Insulin A-Chain, Insulin B-Chain 著者 Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A. 登録日 2016-01-21 公開日 2017-01-25 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (0.97 Å) 主引用文献 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation. J. Am. Chem. Soc., 139, 2017
5HPU	Insulin with proline analog HyP at position B28 in the R6 state 分子名称: CHLORIDE ION, Insulin, chain A, ... 著者 Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A. 登録日 2016-01-21 公開日 2017-01-25 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation. J. Am. Chem. Soc., 139, 2017
5HRQ	Insulin with proline analog HzP at position B28 in the R6 state 分子名称: CHLORIDE ION, Insulin A-Chain, Insulin B-Chain, ... 著者 Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A. 登録日 2016-01-24 公開日 2017-01-25 最終更新日 2020-01-15 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation. J. Am. Chem. Soc., 139, 2017
5UDP	High resolution x-ray crystal structure of synthetic insulin lispro 分子名称: CHLORIDE ION, Insulin Lispro A chain, Insulin Lispro B chain, ... 著者 Mandal, K, Dhayalan, B, Kent, S.B.H. 登録日 2016-12-28 公開日 2017-01-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.348 Å) 主引用文献 Scope and Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin. Chemistry, 23, 2017
5EMS	Crystal Structure of an iodinated insulin analog 分子名称: CHLORIDE ION, Insulin, PHENOL, ... 著者 Lawrence, M.C, Pandyarajan, V, Wan, Z, Weiss, M.A. 登録日 2015-11-06 公開日 2016-11-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY. J. Biol. Chem., 291, 2016
5E7W	X-ray Structure of Human Recombinant 2Zn insulin at 0.92 Angstrom 分子名称: ACETATE ION, Insulin, N-PROPANOL, ... 著者 Lisgarten, D.R, Naylor, C.E, Palmer, R.A, Lobley, C.M.C. 登録日 2015-10-13 公開日 2016-10-12 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (0.9519 Å) 主引用文献 Ultra-high resolution X-ray structures of two forms of human recombinant insulin at 100 K. Chem Cent J, 11, 2017
5L3N	D11 bound [N29, S39_PQ]-IGF-II 分子名称: Insulin-like growth factor II 著者 Hexnerova, R. 登録日 2016-05-23 公開日 2016-08-10 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. J.Biol.Chem., 291, 2016
5L3L	D11 bound IGF-II 分子名称: Insulin-like growth factor II 著者 Hexnerova, R. 登録日 2016-05-23 公開日 2016-08-10 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. J.Biol.Chem., 291, 2016
5L3M	D11 bound [S39_PQ]-IGF-II 分子名称: Insulin-like growth factor II 著者 Hexnerova, R. 登録日 2016-05-23 公開日 2016-08-10 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. J.Biol.Chem., 291, 2016
5LIS	Insulin solved by Native SAD from a dataset collected in one second 分子名称: Insulin 著者 Casanas, A, Finke, A, Wang, M. 登録日 2016-07-15 公開日 2016-08-03 最終更新日 2016-09-28 実験手法 X-RAY DIFFRACTION (2.293 Å) 主引用文献 EIGER detector: application in macromolecular crystallography. Acta Crystallogr D Struct Biol, 72, 2016
5FB6	Room-temperature macromolecular crystallography using a micro-patterned silicon chip with minimal background scattering 分子名称: Insulin Chain A, Insulin Chain B 著者 Roedig, P, Duman, R, Sanchez-Weatherby, J, Vartiainen, I, Burkhardt, A, Warmer, M, David, C, Wagner, A, Meents, A. 登録日 2015-12-14 公開日 2016-06-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.901 Å) 主引用文献 Room-temperature macromolecular crystallography using a micro-patterned silicon chip with minimal background scattering. J.Appl.Crystallogr., 49, 2016
5BTS	Structural and biophysical characterization of a covalent insulin dimer formed during storage of neutral formulation of human insulin 分子名称: Insulin A chain, Insulin B chain 著者 Norrman, M, Hjorth, C.F. 登録日 2015-06-03 公開日 2016-03-09 最終更新日 2019-02-20 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Structure, Aggregation, and Activity of a Covalent Insulin Dimer Formed During Storage of Neutral Formulation of Human Insulin. J.Pharm.Sci., 105, 2016
5BOQ	Human insulin with intra-chain chemical crosslink between modified B24 and B29 分子名称: Insulin, SULFATE ION 著者 Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. 登録日 2015-05-27 公開日 2016-02-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 6, 2016

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