High resolution x-ray crystal structure of synthetic insulin lispro

Summary for 5UDP

DescriptorInsulin Lispro A chain, Insulin Lispro B chain, PHENOL, ... (7 entities in total)
Functional Keywordsinsulin lispro, chemical protein synthesis, fmoc chemistry, hormone
Biological sourceHomo sapiens (Human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains12
Total molecular weight35695.29
Mandal, K.,Dhayalan, B.,Kent, S.B.H. (deposition date: 2016-12-28, release date: 2017-01-11, Last modification date: 2017-09-27)
Primary citation
Dhayalan, B.,Mandal, K.,Rege, N.,Weiss, M.A.,Eitel, S.H.,Meier, T.,Schoenleber, R.O.,Kent, S.B.
Scope and Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin.
Chemistry, 23:1709-1716, 2017
PubMed: 27905149 (PDB entries with the same primary citation)
DOI: 10.1002/chem.201605578
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.19480 0.4% 24.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-28