5WDM

An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein

Summary for 5WDM

Entry DOI	10.2210/pdb5wdm/pdb
Descriptor	Single-chain insulin analog (1 entity in total)
Functional Keywords	single chain, hexamer, designed insulin, hormone
Biological source	Homo sapiens (Human)
Cellular location	Secreted : A6XGL2
Total number of polymer chains	6
Total formula weight	39176.00
Authors	Yee, V.C.,Aldabbagh, K.,Peng, Y. (deposition date: 2017-07-05, release date: 2017-11-15, Last modification date: 2023-10-04)
Primary citation	Glidden, M.D.,Aldabbagh, K.,Phillips, N.B.,Carr, K.,Chen, Y.S.,Whittaker, J.,Phillips, M.,Wickramasinghe, N.P.,Rege, N.,Swain, M.,Peng, Y.,Yang, Y.,Lawrence, M.C.,Yee, V.C.,Ismail-Beigi, F.,Weiss, M.A. An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein. J. Biol. Chem., 293:47-68, 2018 Cited by PubMed: 29114035 DOI: 10.1074/jbc.M117.808626 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.803 Å)

Structure validation