5WDM
An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein
Summary for 5WDM
Entry DOI | 10.2210/pdb5wdm/pdb |
Descriptor | Single-chain insulin analog (1 entity in total) |
Functional Keywords | single chain, hexamer, designed insulin, hormone |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted : A6XGL2 |
Total number of polymer chains | 6 |
Total formula weight | 39176.00 |
Authors | Yee, V.C.,Aldabbagh, K.,Peng, Y. (deposition date: 2017-07-05, release date: 2017-11-15, Last modification date: 2023-10-04) |
Primary citation | Glidden, M.D.,Aldabbagh, K.,Phillips, N.B.,Carr, K.,Chen, Y.S.,Whittaker, J.,Phillips, M.,Wickramasinghe, N.P.,Rege, N.,Swain, M.,Peng, Y.,Yang, Y.,Lawrence, M.C.,Yee, V.C.,Ismail-Beigi, F.,Weiss, M.A. An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein. J. Biol. Chem., 293:47-68, 2018 Cited by PubMed: 29114035DOI: 10.1074/jbc.M117.808626 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.803 Å) |
Structure validation
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