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5WBK
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Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human S6K1
分子名称: Regulatory-associated protein of TOR 1, Ribosomal protein S6 kinase beta-1
著者Pavletich, N.P, Jiang, X.
登録日2017-06-29
公開日2017-12-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
5WBI
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BU of 5wbi by Molmil
Crystal structure of the Arabidopsis thaliana Raptor
分子名称: Regulatory-associated protein of TOR 1
著者Pavletich, N.P, Jiang, X.
登録日2017-06-29
公開日2017-12-20
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
5WBJ
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Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human 4EBP1
分子名称: Eukaryotic translation initiation factor 4E-binding protein 1, Regulatory-associated protein of TOR 1
著者Pavletich, N.P, Jiang, X.
登録日2017-06-29
公開日2017-12-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
3L54
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Structure of Pi3K gamma with inhibitor
分子名称: 6-(1H-pyrazolo[3,4-b]pyridin-5-yl)-4-pyridin-4-ylquinoline, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION
著者Elkins, P.A, Smallwood, A.M.
登録日2009-12-21
公開日2010-06-30
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin.
ACS Med Chem Lett, 1, 2010
5BXV
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BU of 5bxv by Molmil
eIF4E complex
分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1
著者Sekiyama, N, Arthanari, H, Papdopoulos, E, Rodriguez-Mias, R.A, Wagner, G, Leger-Abraham, M.
登録日2015-06-09
公開日2015-07-15
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1.
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZC4
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BU of 4zc4 by Molmil
Crystal structure of LARP1-unique domain DM15
分子名称: La-related protein 1, SULFATE ION
著者Lahr, R.M, Berman, A.J.
登録日2015-04-15
公開日2015-08-05
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5'TOP sequence.
Nucleic Acids Res., 43, 2015
2MX4
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BU of 2mx4 by Molmil
NMR structure of Phosphorylated 4E-BP2
分子名称: Eukaryotic translation initiation factor 4E-binding protein 2
著者Bah, A, Forman-Kay, J, Vernon, R, Siddiqui, Z, Krzeminski, M, Muhandiram, R, Zhao, C, Sonenberg, N, Kay, L.
登録日2014-12-10
公開日2015-01-07
最終更新日2015-03-18
実験手法SOLUTION NMR
主引用文献Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch.
Nature, 519, 2015
4UED
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BU of 4ued by Molmil
Complex of human eIF4E with the 4E binding protein 4E-BP1
分子名称: EUKARYOTIC TRANSLATION FACTOR 4E-BINDING PROTEIN 1, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
著者Peter, D, Weichenrieder, O.
登録日2014-12-16
公開日2015-02-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Molecular Architecture of 4E-BP Translational Inhibitors Bound to Eif4E.
Mol.Cell, 57, 2015
5VOK
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Crystal structure of the C7orf59-HBXIP dimer
分子名称: Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5
著者Rasheed, N, Nascimento, A.F.Z, Bar-Peled, L, Shen, K, Sabatini, D.M, Aparicio, R, Smetana, J.H.C.
登録日2017-05-03
公開日2018-05-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献C7orf59/Lamtor4 phosphorylation and structural flexibility modulate Ragulator assembly.
Febs Open Bio, 2019
6XK9
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BU of 6xk9 by Molmil
Cereblon in complex with DDB1, CC-90009, and GSPT1
分子名称: 2-(4-chlorophenyl)-N-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ...
著者Clayton, T.L, Tran, E.T, Zhu, J, Pagarigan, B.E, Matyskiela, M.E, Chamberlain, P.P.
登録日2020-06-25
公開日2020-12-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.64 Å)
主引用文献CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells.
Blood, 137, 2021
6Z6M
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BU of 6z6m by Molmil
Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1
分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ...
著者Wells, J.N, Buschauer, R, Mackens-Kiani, T, Best, K, Kratzat, H, Berninghausen, O, Becker, T, Cheng, J, Beckmann, R.
登録日2020-05-28
公開日2020-07-29
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.
Plos Biol., 18, 2020
6Z6N
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BU of 6z6n by Molmil
Cryo-EM structure of human EBP1-80S ribosomes (focus on EBP1)
分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ...
著者Wells, J.N, Buschauer, R, Mackens-Kiani, T, Best, K, Kratzat, H, Berninghausen, O, Becker, T, Cheng, J, Beckmann, R.
登録日2020-05-28
公開日2020-07-29
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.
Plos Biol., 18, 2020
3NR5
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BU of 3nr5 by Molmil
Crystal structure of human Maf1
分子名称: Repressor of RNA polymerase III transcription MAF1 homolog
著者Ringel, R, Vannini, A, Kusser, A.G, Berninghausen, O, Kassavetis, G.A, Cramer, P.
登録日2010-06-30
公開日2010-10-13
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Molecular Basis of RNA Polymerase III Transcription Repression by Maf1
Cell(Cambridge,Mass.), 143, 2010
6SYT
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BU of 6syt by Molmil
Structure of the SMG1-SMG8-SMG9 complex
分子名称: ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ...
著者Gat, Y, Schuller, J.M, Conti, E.
登録日2019-10-01
公開日2019-12-11
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.45 Å)
主引用文献InsP6binding to PIKK kinases revealed by the cryo-EM structure of an SMG1-SMG8-SMG9 complex.
Nat.Struct.Mol.Biol., 26, 2019
5NVN
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Crystal structure of the human 4EHP-4E-BP1 complex
分子名称: Eukaryotic translation initiation factor 4E type 2, Eukaryotic translation initiation factor 4E-binding protein 1, FORMIC ACID
著者Peter, D, Sandmeir, F, Valkov, E.
登録日2017-05-04
公開日2017-07-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.
Genes Dev., 31, 2017
4OYS
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BU of 4oys by Molmil
CRYSTAL STRUCTURE OF VPS34 IN COMPLEX WITH SAR405.
分子名称: (8S)-9-[(5-chloranylpyridin-3-yl)methyl]-2-[(3R)-3-methylmorpholin-4-yl]-8-(trifluoromethyl)-6,7,8,9a-tetrahydro-3H-pyrimido[1,2-a]pyrimidin-4-one, Phosphatidylinositol 3-kinase catalytic subunit type 3, SULFATE ION
著者Mathieu, M, Marquette, J.p.
登録日2014-02-13
公開日2014-10-22
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy.
Nat.Chem.Biol., 10, 2014
7K6O
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BU of 7k6o by Molmil
Crystal structure of PI3Kalpha inhibitor 10-5429
分子名称: (3S)-3-[4-(2-aminopyrimidin-5-yl)-2-(morpholin-4-yl)-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-N-methylpyrrolidine-1-sulfonamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Chen, P, Brooun, A, Deng, Y.L, Grodsky, N, Kaiser, S.E.
登録日2020-09-21
公開日2021-01-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.738 Å)
主引用文献Structure-Based Drug Design and Synthesis of PI3K alpha-Selective Inhibitor (PF-06843195).
J.Med.Chem., 64, 2021
7K71
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Crystal structure of PI3Kalpha inhibitor 4-0686
分子名称: 2-(morpholin-4-yl)[4,5'-bipyrimidin]-2'-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Chen, P, Brooun, A, Deng, Y.L, Grodsky, N, Kaiser, S.E.
登録日2020-09-21
公開日2021-01-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure-Based Drug Design and Synthesis of PI3K alpha-Selective Inhibitor (PF-06843195).
J.Med.Chem., 64, 2021
7K6N
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Crystal structure of PI3Kalpha selective Inhibitor 11-1575
分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, tert-butyl (3S)-3-[4-(2-aminopyrimidin-5-yl)-2-(morpholin-4-yl)-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-3-methylpyrrolidine-1-carboxylate
著者Chen, P, Brooun, A, Deng, Y.L, Grodsky, N, Kaiser, S.E.
登録日2020-09-21
公開日2021-01-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献Structure-Based Drug Design and Synthesis of PI3K alpha-Selective Inhibitor (PF-06843195).
J.Med.Chem., 64, 2021
7K6M
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Crystal structure of PI3Kalpha selective Inhibitor PF-06843195
分子名称: 2,2-difluoroethyl (3S)-3-{[2'-amino-5-fluoro-2-(morpholin-4-yl)[4,5'-bipyrimidin]-6-yl]amino}-3-(hydroxymethyl)pyrrolidine-1-carboxylate, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Chen, P, Brooun, A, Deng, Y.L, Grodsky, N, Kaiser, S.E.
登録日2020-09-21
公開日2021-01-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.413 Å)
主引用文献Structure-Based Drug Design and Synthesis of PI3K alpha-Selective Inhibitor (PF-06843195).
J.Med.Chem., 64, 2021
5C0V
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Structure of the LARP1-unique domain DM15
分子名称: La-related protein 1, SULFATE ION
著者Lahr, R.M, Berman, A.J.
登録日2015-06-12
公開日2015-08-05
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5'TOP sequence.
Nucleic Acids Res., 43, 2015
6CHZ
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Estrogen Receptor Alpha Y537S bound to antagonist H3B-9224.
分子名称: 1,2-ETHANEDIOL, 4-[(2-{4-[(1E)-1-(1H-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide, Estrogen receptor
著者Larsen, N.A.
登録日2018-02-23
公開日2018-03-21
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ER alphaWTand ER alphaMUTBreast Cancer.
Cancer Discov, 8, 2018
6CHW
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Estrogen Receptor Alpha Y537S covalently bound to antagonist H3B-5942.
分子名称: 1,2-ETHANEDIOL, 4-[(2-{4-[(1E)-1-(1H-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide, DIMETHYL SULFOXIDE, ...
著者Larsen, N.A.
登録日2018-02-23
公開日2018-03-21
最終更新日2020-02-26
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ER alphaWTand ER alphaMUTBreast Cancer.
Cancer Discov, 8, 2018
6D5Y
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Crystal structure of ERK2 G169D mutant
分子名称: Mitogen-activated protein kinase 1
著者Yin, J, Jaiswal, B.S, Wang, W.
登録日2018-04-19
公開日2019-02-27
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.86 Å)
主引用文献ERK Mutations and Amplification Confer Resistance to ERK-Inhibitor Therapy.
Clin. Cancer Res., 24, 2018
5Y38
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Crystal structure of C7orf59-HBXIP complex
分子名称: Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5, SULFATE ION
著者Zhang, T, Ding, J.
登録日2017-07-28
公開日2017-12-06
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
Nat Commun, 8, 2017

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