6NZD

Cryo-EM Structure of the Lysosomal Folliculin Complex (FLCN-FNIP2-RagA-RagC-Ragulator)

Summary for 6NZD

Entry DOI	10.2210/pdb6nzd/pdb
EMDB information	0554 0556
Descriptor	Ragulator complex protein LAMTOR1, GUANOSINE-5'-DIPHOSPHATE, 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(thiophosphonooxy)phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-3,9-dihydro-1H-purine-2,6-dione, ... (11 entities in total)
Functional Keywords	lysosome, mtorc1 regulation, amino acid sensing, gtpase, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	9
Total formula weight	348515.78
Authors	Fromm, S.A.,Young, L.N.,Hurley, J.H. (deposition date: 2019-02-13, release date: 2019-11-06, Last modification date: 2019-12-18)
Primary citation	Lawrence, R.E.,Fromm, S.A.,Fu, Y.,Yokom, A.L.,Kim, D.J.,Thelen, A.M.,Young, L.N.,Lim, C.Y.,Samelson, A.J.,Hurley, J.H.,Zoncu, R. Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex. Science, 366:971-977, 2019 Cited by PubMed: 31672913 DOI: 10.1126/science.aax0364 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.6 Å)

Structure validation