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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6NZD

Cryo-EM Structure of the Lysosomal Folliculin Complex (FLCN-FNIP2-RagA-RagC-Ragulator)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001558biological_processregulation of cell growth
A0001919biological_processregulation of receptor recycling
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005515molecular_functionprotein binding
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005886cellular_componentplasma membrane
A0007032biological_processendosome organization
A0007040biological_processlysosome organization
A0008104biological_processintracellular protein localization
A0010874biological_processregulation of cholesterol efflux
A0016197biological_processendosomal transport
A0031669biological_processcellular response to nutrient levels
A0031902cellular_componentlate endosome membrane
A0032008biological_processpositive regulation of TOR signaling
A0032418biological_processlysosome localization
A0035577cellular_componentazurophil granule membrane
A0035579cellular_componentspecific granule membrane
A0038202biological_processTORC1 signaling
A0042632biological_processcholesterol homeostasis
A0043410biological_processpositive regulation of MAPK cascade
A0043495molecular_functionprotein-membrane adaptor activity
A0045121cellular_componentmembrane raft
A0051020molecular_functionGTPase binding
A0060090molecular_functionmolecular adaptor activity
A0060620biological_processregulation of cholesterol import
A0070062cellular_componentextracellular exosome
A0071230biological_processcellular response to amino acid stimulus
A0071986cellular_componentRagulator complex
A0072657biological_processprotein localization to membrane
A0101003cellular_componentficolin-1-rich granule membrane
A0150032biological_processpositive regulation of protein localization to lysosome
A1904263biological_processpositive regulation of TORC1 signaling
A1990877cellular_componentFNIP-folliculin RagC/D GAP
B0001558biological_processregulation of cell growth
B0005085molecular_functionguanyl-nucleotide exchange factor activity
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005770cellular_componentlate endosome
B0005886cellular_componentplasma membrane
B0008104biological_processintracellular protein localization
B0010008cellular_componentendosome membrane
B0031902cellular_componentlate endosome membrane
B0032008biological_processpositive regulation of TOR signaling
B0035579cellular_componentspecific granule membrane
B0038202biological_processTORC1 signaling
B0060090molecular_functionmolecular adaptor activity
B0070821cellular_componenttertiary granule membrane
B0071230biological_processcellular response to amino acid stimulus
B0071986cellular_componentRagulator complex
B0150116biological_processregulation of cell-substrate junction organization
B1902533biological_processpositive regulation of intracellular signal transduction
B1904263biological_processpositive regulation of TORC1 signaling
B1990877cellular_componentFNIP-folliculin RagC/D GAP
C0005085molecular_functionguanyl-nucleotide exchange factor activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005770cellular_componentlate endosome
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0008104biological_processintracellular protein localization
C0010008cellular_componentendosome membrane
C0019209molecular_functionkinase activator activity
C0031902cellular_componentlate endosome membrane
C0032006biological_processregulation of TOR signaling
C0032008biological_processpositive regulation of TOR signaling
C0035579cellular_componentspecific granule membrane
C0038202biological_processTORC1 signaling
C0060090molecular_functionmolecular adaptor activity
C0070062cellular_componentextracellular exosome
C0070821cellular_componenttertiary granule membrane
C0071230biological_processcellular response to amino acid stimulus
C0071986cellular_componentRagulator complex
C1902533biological_processpositive regulation of intracellular signal transduction
C1904263biological_processpositive regulation of TORC1 signaling
C1990877cellular_componentFNIP-folliculin RagC/D GAP
D0005085molecular_functionguanyl-nucleotide exchange factor activity
D0005515molecular_functionprotein binding
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0008361biological_processregulation of cell size
D0031902cellular_componentlate endosome membrane
D0032008biological_processpositive regulation of TOR signaling
D0038202biological_processTORC1 signaling
D0060090molecular_functionmolecular adaptor activity
D0061462biological_processprotein localization to lysosome
D0071230biological_processcellular response to amino acid stimulus
D0071986cellular_componentRagulator complex
D1904263biological_processpositive regulation of TORC1 signaling
D1990877cellular_componentFNIP-folliculin RagC/D GAP
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005764cellular_componentlysosome
E0005765cellular_componentlysosomal membrane
E0005829cellular_componentcytosol
E0008361biological_processregulation of cell size
E0009615biological_processresponse to virus
E0010628biological_processpositive regulation of gene expression
E0019079biological_processviral genome replication
E0031902cellular_componentlate endosome membrane
E0032008biological_processpositive regulation of TOR signaling
E0032757biological_processpositive regulation of interleukin-8 production
E0032991cellular_componentprotein-containing complex
E0038202biological_processTORC1 signaling
E0043066biological_processnegative regulation of apoptotic process
E0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
E0060090molecular_functionmolecular adaptor activity
E0061462biological_processprotein localization to lysosome
E0071230biological_processcellular response to amino acid stimulus
E0071986cellular_componentRagulator complex
E1900182biological_processpositive regulation of protein localization to nucleus
E1904263biological_processpositive regulation of TORC1 signaling
E1990877cellular_componentFNIP-folliculin RagC/D GAP
F0000166molecular_functionnucleotide binding
F0003924molecular_functionGTPase activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005764cellular_componentlysosome
F0005765cellular_componentlysosomal membrane
F0005829cellular_componentcytosol
F0006915biological_processapoptotic process
F0008104biological_processintracellular protein localization
F0009267biological_processcellular response to starvation
F0010507biological_processnegative regulation of autophagy
F0016787molecular_functionhydrolase activity
F0031625molecular_functionubiquitin protein ligase binding
F0031669biological_processcellular response to nutrient levels
F0032008biological_processpositive regulation of TOR signaling
F0033209biological_processtumor necrosis factor-mediated signaling pathway
F0034198biological_processcellular response to amino acid starvation
F0035556biological_processintracellular signal transduction
F0042593biological_processglucose homeostasis
F0042803molecular_functionprotein homodimerization activity
F0043495molecular_functionprotein-membrane adaptor activity
F0046982molecular_functionprotein heterodimerization activity
F0051219molecular_functionphosphoprotein binding
F0061462biological_processprotein localization to lysosome
F0071230biological_processcellular response to amino acid stimulus
F0072657biological_processprotein localization to membrane
F1904263biological_processpositive regulation of TORC1 signaling
F1990130cellular_componentGATOR1 complex
F1990131cellular_componentGtr1-Gtr2 GTPase complex
F1990877cellular_componentFNIP-folliculin RagC/D GAP
G0000166molecular_functionnucleotide binding
G0000287molecular_functionmagnesium ion binding
G0003924molecular_functionGTPase activity
G0005515molecular_functionprotein binding
G0005525molecular_functionGTP binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005764cellular_componentlysosome
G0005765cellular_componentlysosomal membrane
G0005829cellular_componentcytosol
G0006351biological_processDNA-templated transcription
G0006915biological_processapoptotic process
G0007264biological_processsmall GTPase-mediated signal transduction
G0008104biological_processintracellular protein localization
G0008380biological_processRNA splicing
G0009267biological_processcellular response to starvation
G0010507biological_processnegative regulation of autophagy
G0016787molecular_functionhydrolase activity
G0019003molecular_functionGDP binding
G0031669biological_processcellular response to nutrient levels
G0032006biological_processregulation of TOR signaling
G0034198biological_processcellular response to amino acid starvation
G0043200biological_processresponse to amino acid
G0043495molecular_functionprotein-membrane adaptor activity
G0046982molecular_functionprotein heterodimerization activity
G0051020molecular_functionGTPase binding
G0060090molecular_functionmolecular adaptor activity
G0061462biological_processprotein localization to lysosome
G0071230biological_processcellular response to amino acid stimulus
G0072657biological_processprotein localization to membrane
G0140767molecular_functionenzyme-substrate adaptor activity
G1903432biological_processregulation of TORC1 signaling
G1904263biological_processpositive regulation of TORC1 signaling
G1990131cellular_componentGtr1-Gtr2 GTPase complex
G1990877cellular_componentFNIP-folliculin RagC/D GAP
H0000122biological_processnegative regulation of transcription by RNA polymerase II
H0001701biological_processin utero embryonic development
H0004857molecular_functionenzyme inhibitor activity
H0005096molecular_functionGTPase activator activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005764cellular_componentlysosome
H0005765cellular_componentlysosomal membrane
H0005813cellular_componentcentrosome
H0005819cellular_componentspindle
H0005829cellular_componentcytosol
H0005929cellular_componentcilium
H0007043biological_processcell-cell junction assembly
H0009267biological_processcellular response to starvation
H0010508biological_processpositive regulation of autophagy
H0019899molecular_functionenzyme binding
H0030097biological_processhemopoiesis
H0030496cellular_componentmidbody
H0030511biological_processpositive regulation of transforming growth factor beta receptor signaling pathway
H0032006biological_processregulation of TOR signaling
H0032007biological_processnegative regulation of TOR signaling
H0032008biological_processpositive regulation of TOR signaling
H0032418biological_processlysosome localization
H0034198biological_processcellular response to amino acid starvation
H0035024biological_processnegative regulation of Rho protein signal transduction
H0035556biological_processintracellular signal transduction
H0043065biological_processpositive regulation of apoptotic process
H0044291cellular_componentcell-cell contact zone
H0044877molecular_functionprotein-containing complex binding
H0045820biological_processnegative regulation of glycolytic process
H0045892biological_processnegative regulation of DNA-templated transcription
H0046578biological_processregulation of Ras protein signal transduction
H0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
H0070373biological_processnegative regulation of ERK1 and ERK2 cascade
H0072686cellular_componentmitotic spindle
H0097009biological_processenergy homeostasis
H0120163biological_processnegative regulation of cold-induced thermogenesis
H1901723biological_processnegative regulation of cell proliferation involved in kidney development
H1901874biological_processnegative regulation of post-translational protein modification
H1902532biological_processnegative regulation of intracellular signal transduction
H1903444biological_processnegative regulation of brown fat cell differentiation
H1904263biological_processpositive regulation of TORC1 signaling
H1905672biological_processnegative regulation of lysosome organization
H1990877cellular_componentFNIP-folliculin RagC/D GAP
H2000973biological_processregulation of pro-B cell differentiation
I0000122biological_processnegative regulation of transcription by RNA polymerase II
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005765cellular_componentlysosomal membrane
I0005829cellular_componentcytosol
I0006974biological_processDNA damage response
I0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
I0031334biological_processpositive regulation of protein-containing complex assembly
I0032007biological_processnegative regulation of TOR signaling
I0034451cellular_componentcentriolar satellite
I0042030molecular_functionATPase inhibitor activity
I0051087molecular_functionprotein-folding chaperone binding
I1904263biological_processpositive regulation of TORC1 signaling
I1990877cellular_componentFNIP-folliculin RagC/D GAP
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue GDP F 500
ChainResidue
FLYS15
FASP130
FSER163
FILE164
FTRP165
HARG122
HVAL126
IALA147
FSER16
FGLY17
FSER18
FGLY19
FLYS20
FTHR21
FHIS127
FLYS128
site_idAC2
Number of Residues16
Detailsbinding site for residue L8S G 500
ChainResidue
GARG70
GARG71
GSER72
GGLY73
GLYS74
GSER75
GSER76
GTHR90
GLEU91
GTHR96
GPRO118
GGLY119
GHIS178
GLYS179
GASN181
GILE220
Functional Information from PROSITE/UniProt
site_idPS00214
Number of Residues18
DetailsFABP Cytosolic fatty-acid binding proteins signature. KAYkVnpDmNFEvFIHKV
ChainResidueDetails
GLYS163-VAL180
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36476874","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q9CQ22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues13
DetailsRegion: {"description":"Required for location at endosomes","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues13
DetailsRegion: {"description":"Required for interaction with LAMTOR2","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"31314152","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36103527","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DHB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31672913","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31704029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ULG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31704029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ULG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"25936802","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q99K70","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues10
DetailsRegion: {"description":"Essential for interaction with LDHA","evidences":[{"source":"PubMed","id":"34381247","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues1
DetailsSite: {"description":"Essential for GTPase activation (GAP) activity","evidences":[{"source":"PubMed","id":"31672913","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31704029","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine; by ULK1","evidences":[{"source":"PubMed","id":"25126726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2025-12-24

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