PDB: 5470 件ウェブページステータス検索Chemie searchBIRD

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4MI0	Human Enhancer of Zeste (Drosophila) Homolog 2(EZH2) 分子名称: Histone-lysine N-methyltransferase EZH2, UNKNOWN ATOM OR ION, ZINC ION 著者 Dong, A, Zeng, H, He, H, Wernimont, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) 登録日 2013-08-30 公開日 2013-09-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations. Plos One, 8, 2013
7B51	Crystal structure of human CRM1 covalently modified by 2-mercaptoethanol at Cys528 分子名称: BETA-MERCAPTOETHANOL, Exportin-1, GTP-binding nuclear protein Ran, ... 著者 Shaikhqasem, A, Ficner, R. 登録日 2020-12-03 公開日 2021-03-10 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Crystal structure of human CRM1, covalently modified by 2-mercaptoethanol on Cys528, in complex with RanGTP. Acta Crystallogr.,Sect.F, 77, 2021
4LYW	Crystal Structure of BRD4(1) bound to inhibitor XD14 分子名称: 4-acetyl-N-[5-(diethylsulfamoyl)-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4 著者 Wohlwend, D, Gerhardt, S, Einsle, O. 登録日 2013-07-31 公開日 2014-01-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew.Chem.Int.Ed.Engl., 52, 2013
4LZR	Crystal Structure of BRD4(1) bound to Colchicine 分子名称: Bromodomain-containing protein 4, N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide 著者 Wohlwend, D, Gerhardt, S, Einsle, O, Huegle, M. 登録日 2013-08-01 公開日 2014-01-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew.Chem.Int.Ed.Engl., 52, 2013
4LXZ	Structure of Human HDAC2 in complex with SAHA (vorinostat) 分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, Histone deacetylase 2, ... 著者 Fong, R, Lupardus, P.J. 登録日 2013-07-30 公開日 2013-08-21 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability. J.Biol.Chem., 288, 2013
4LZS	Crystal Structure of BRD4(1) bound to inhibitor XD46 分子名称: 4-acetyl-3-ethyl-N,5-dimethyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4 著者 Wohlwend, D, Huegle, M, Einsle, O, Gerhardt, S. 登録日 2013-08-01 公開日 2014-01-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew.Chem.Int.Ed.Engl., 52, 2013
4LYI	Crystal Structure of apo-BRD4(1) 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, IODIDE ION, ... 著者 Wohlwend, D. 登録日 2013-07-31 公開日 2014-01-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew.Chem.Int.Ed.Engl., 52, 2013
4M49	Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 3-(5-amino-6-{[(1R)-1-phenylethyl]amino}pyrazin-2-yl)-4-chlorobenzoic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Eigenbrot, C, Ultsch, M. 登録日 2013-08-06 公開日 2013-09-04 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.052 Å) 主引用文献 Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase. Bioorg.Med.Chem.Lett., 23, 2013
4MD7	Crystal Structure of full-length symmetric CK2 holoenzyme 分子名称: Casein kinase II subunit alpha, Casein kinase II subunit beta, ZINC ION 著者 Lolli, G, Ranchio, A, Battistutta, R. 登録日 2013-08-22 公開日 2013-11-20 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Active Form of the Protein Kinase CK2 alpha 2 beta 2 Holoenzyme Is a Strong Complex with Symmetric Architecture. Acs Chem.Biol., 9, 2014
2KG0	Structure of the second qRRM domain of hnRNP F in complex with a AGGGAU G-tract RNA 分子名称: 5'-R(*AP*GP*GP*GP*AP*U)-3', Heterogeneous nuclear ribonucleoprotein F 著者 Allain, F.H.T, Dominguez, C. 登録日 2009-03-02 公開日 2010-06-09 最終更新日 2024-05-08 実験手法 SOLUTION NMR 主引用文献 Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs. Nat.Struct.Mol.Biol., 17, 2010
7B7Z	DeAMPylation complex of monomeric FICD and AMPylated BiP (state 1) 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE MONOPHOSPHATE, Endoplasmic reticulum chaperone BiP, ... 著者 Perera, L.A, Ron, D. 登録日 2020-12-12 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD. Nat Commun, 12, 2021
7B80	DeAMPylation complex of monomeric FICD and AMPylated BiP (state 2) 分子名称: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... 著者 Perera, L.A, Ron, D. 登録日 2020-12-12 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD. Nat Commun, 12, 2021
2KFY	NMR structure of the first qRRM of hnRNP F in complex with AGGGAU G-tract RNA 分子名称: 5'-R(*AP*GP*GP*GP*AP*U)-3', Heterogeneous nuclear ribonucleoprotein F 著者 Allain, F.H.T, Dominguez, C. 登録日 2009-03-02 公開日 2010-06-09 最終更新日 2024-05-08 実験手法 SOLUTION NMR 主引用文献 Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs. Nat.Struct.Mol.Biol., 17, 2010
7APO	Crystal structure of RARalpha ligand binding domain in complex with a fragment of the TIF2 coactivator 分子名称: 4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid, GLYCEROL, Nuclear receptor coactivator 2, ... 著者 le Maire, A, Guee, L, Bourguet, W. 登録日 2020-10-19 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR). J.Mol.Biol., 433, 2021
4MR3	Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolinone ligand (RVX-OH) 分子名称: 1,2-ETHANEDIOL, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one, Bromodomain-containing protein 4 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Martin, S, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-09-17 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. Proc.Natl.Acad.Sci.USA, 110, 2013
2KPW	NMR solution structure of Lamin-B1 protein from Homo sapiens: Northeast Structural Genomics Consortium MEGA target, HR5546A (439-549) 分子名称: Lamin-B1 著者 Swapna, G.V.T, Ciccosanti, C.L, Belote, R, Hamilton, K, Acton, T, Huang, Y, Xiao, R, Everett, J, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) 登録日 2009-10-21 公開日 2009-11-10 最終更新日 2024-05-08 実験手法 SOLUTION NMR 主引用文献 NMR solution structure of Lamin-B1 protein from Homo sapiens: Northeast Structural Genomics Consortium target, HR5546A (439-549) To be Published
7AXR	Crystal structure of BRD4(1) bound to the dual BET-HDAC inhibitor LSH24 分子名称: 4-acetyl-3-ethyl-N-(3-(3-(hydroxyamino)-3-oxopropyl)phenyl)-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4 著者 Huegle, M. 登録日 2020-11-10 公開日 2021-10-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads. J.Med.Chem., 64, 2021
7B00	Human LAT2-4F2hc complex in the apo-state 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Digitonin, Isoform 2 of 4F2 cell-surface antigen heavy chain, ... 著者 Rodriguez, C.F, Escudero-Bravo, P, Garcia-Martin, C, Boskovic, J, Errasti-Murugarren, E, Palacin, M, Llorca, O. 登録日 2020-11-17 公開日 2021-10-27 最終更新日 2022-02-23 実験手法 ELECTRON MICROSCOPY (3.98 Å) 主引用文献 Structural basis for substrate specificity of heteromeric transporters of neutral amino acids. Proc Natl Acad Sci U S A, 118, 2021
2KDP	Solution Structure of the SAP30 zinc finger motif 分子名称: Histone deacetylase complex subunit SAP30, ZINC ION 著者 He, Y, Imhoff, R, Sahu, A, Radhakrishnan, I. 登録日 2009-01-14 公開日 2009-03-17 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution structure of a novel zinc finger motif in the SAP30 polypeptide of the Sin3 corepressor complex and its potential role in nucleic acid recognition Nucleic Acids Res., 37, 2009
2KIZ	Solution structure of Arkadia RING-H2 finger domain 分子名称: E3 ubiquitin-protein ligase Arkadia, ZINC ION 著者 Kandias, N.G, Chasapis, C.T, Bentrop, D, Episkopou, V, Spyroulias, G.A. 登録日 2009-05-13 公開日 2010-05-19 最終更新日 2013-03-20 実験手法 SOLUTION NMR 主引用文献 NMR-based insights into the conformational and interaction properties of Arkadia RING-H2 E3 Ub ligase. Proteins, 80, 2012
2KTU	Human eRF1 C-domain, "closed" conformer 分子名称: Eukaryotic peptide chain release factor subunit 1 著者 Mantsyzov, A.B, Polshakov, V.I, Birdsall, B. 登録日 2010-02-09 公開日 2010-06-09 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 NMR assignments of the C-terminal domain of human polypeptide release factor eRF1. Biomol.Nmr Assign., 1, 2007
2KNV	NMR dimer structure of the UBA domain of p62 (SQSTM1) 分子名称: Sequestosome-1 著者 Long, J.E, Searle, M.S. 登録日 2009-09-04 公開日 2009-12-15 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Dimerisation of the UBA Domain of p62 Inhibits Ubiquitin Binding and Regulates NF-kappaB Signalling J.Mol.Biol., 2009
2KRM	RDC refined solution structure of the first SH3 domain of CD2AP 分子名称: CD2-associated protein 著者 Ortega Roldan, J.A.J, Azuaga, A.I, van Nuland, N.A.J. 登録日 2009-12-21 公開日 2011-01-12 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution Structure, Dynamics and Thermodynamics of the three SH3 domains of CD2AP To be Published
2KMD	Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to co-activator CBP 分子名称: Protein C-ets-1 著者 Nelson, M.L, Kang, H, Lee, G.M, Blaszczak, A.G, Lau, D.K.W, McIntosh, L.P, Graves, B.J. 登録日 2009-07-27 公開日 2010-05-05 最終更新日 2012-03-21 実験手法 SOLUTION NMR 主引用文献 Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP. Proc.Natl.Acad.Sci.USA, 107, 2010
2KTB	Solution Structure of the Second Bromodomain of Human Polybromo in complex with an acetylated peptide from Histone 3 分子名称: H3_Peptide, Protein polybromo-1 著者 Charlop-Powers, Z, Zhang, Q, Zeng, L. 登録日 2010-01-26 公開日 2010-05-12 最終更新日 2023-11-15 実験手法 SOLUTION NMR 主引用文献 Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2. Cell Res., 20, 2010

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