6X7U
 
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7K95
 | | Crystal structure of human CPSF30 in complex with hFip1 | | Descriptor: | Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4, Pre-mRNA 3'-end-processing factor FIP1, ZINC ION | | Authors: | Hamilton, K, Tong, L. | | Deposit date: | 2020-09-28 | | Release date: | 2020-11-11 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Molecular mechanism for the interaction between human CPSF30 and hFip1.
Genes Dev., 34, 2020
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6X7V
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1FXT
 | | STRUCTURE OF A CONJUGATING ENZYME-UBIQUITIN THIOLESTER COMPLEX | | Descriptor: | UBIQUITIN, UBIQUITIN-CONJUGATING ENZYME E2-24 KDA | | Authors: | Hamilton, K.S, Shaw, G.S, Williams, R.S, Huzil, J.T, McKenna, S, Ptak, C, Glover, M, Ellison, M.J. | | Deposit date: | 2000-09-26 | | Release date: | 2001-10-10 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structure of a conjugating enzyme-ubiquitin thiolester intermediate reveals a novel role for the ubiquitin tail.
Structure, 9, 2001
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5DIL
 | | Crystal structure of the effector domain of the NS1 protein from influenza virus B | | Descriptor: | IODIDE ION, Non-structural protein 1 | | Authors: | Guan, R, Hamilton, K, Ma, L, Montelione, G.T. | | Deposit date: | 2015-09-01 | | Release date: | 2016-08-10 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | A Second RNA-Binding Site in the NS1 Protein of Influenza B Virus.
Structure, 24, 2016
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2KTA
 | | Solution NMR structure of a domain of protein A6KY75 from Bacteroides vulgatus, Northeast Structural Genomics target BvR106A | | Descriptor: | Putative helicase | | Authors: | Mills, J.L, Sukumaran, D.K, Sathyamoorthy, B, Belote, R.L, Ciccosanti, C, Hamilton, K, Acton, T.B, Xiao, R, Swapna, G.V.T, Everett, J.K, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2010-01-26 | | Release date: | 2010-06-16 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of a domain of protein A6KY75 from Bacteroides vulgatus, Northeast Structural Genomics target BvR106A
To be Published
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2KFP
 | | Solution NMR structure of PSPTO_3016 from Pseudomonas syringae. Northeast Structural Genomics Consortium target PsR293. | | Descriptor: | PSPTO_3016 protein | | Authors: | Feldmann, E.A, Ramelot, T.A, Zhao, L, Hamilton, K, Ciccosanti, C, Xiao, R, Nair, R, Everett, J.K, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2009-02-24 | | Release date: | 2009-03-24 | | Last modified: | 2024-05-08 | | Method: | SOLUTION NMR | | Cite: | Solution NMR and X-ray crystal structures of Pseudomonas syringae Pspto_3016 from protein domain family PF04237 (DUF419) adopt a "double wing" DNA binding motif.
J.Struct.Funct.Genom., 13, 2012
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2KT8
 | | Solution NMR structure of the CPE1231(468-535) protein from Clostridium perfringens, Northeast Structural Genomics Consortium Target CpR82B | | Descriptor: | Probable surface protein | | Authors: | Yang, Y, Ramelot, T.A, Lee, D, Ciccosanti, C, Hamilton, K, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2010-01-21 | | Release date: | 2010-02-02 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of the CPE1231(468-535) protein from Clostridium perfringens, Northeast Structural Genomics Consortium Target CpR82B
To be Published
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2KVO
 | | Solution NMR structure of Photosystem II reaction center Psb28 protein from Synechocystis sp.(strain PCC 6803), Northeast Structural Genomics Consortium Target SgR171 | | Descriptor: | Photosystem II reaction center psb28 protein | | Authors: | Yang, Y, Ramelot, T.A, Cort, J.R, Wang, D, Ciccosanti, C, Hamilton, K, Nair, R, Rost, B, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2010-03-22 | | Release date: | 2010-04-07 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of photosystem II reaction center protein Psb28 from Synechocystis sp. Strain PCC 6803.
Proteins, 79, 2011
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2KQ8
 | | Solution NMR structure of a domain from BT9727_4915 from Bacillus thuringiensis, Northeast Structural Genomics Consortium Target BuR95A | | Descriptor: | Cell wall hydrolase | | Authors: | He, Y, Mills, J.L, Wu, Y, Eletsky, A, Wang, H, Ciccosanti, C, Hamilton, K, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2009-10-30 | | Release date: | 2010-01-26 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of a domain from BT9727_4915 from Bacillus thuringiensis, Northeast Structural Genomics Consortium Target BuR95A
To be Published
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2KW7
 | | Solution NMR Structure of the N-terminal domain of protein PG_0361 from P.gingivalis, Northeast Structural Genomics Consortium Target PgR37A | | Descriptor: | Conserved domain protein | | Authors: | Eletsky, A, Mills, J.L, Lee, D, Ciccosanti, C, Hamilton, K, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2010-03-31 | | Release date: | 2010-04-28 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Solution NMR Structure of the N-terminal domain of protein PG_0361 from P.gingivalis, Northeast Structural Genomics Consortium Target Target PgR37A
To be Published
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2KY4
 | | Solution NMR structure of the PBS linker domain of phycobilisome linker polypeptide from Anabaena sp. Northeast Structural Genomics Consortium Target NsR123E | | Descriptor: | Phycobilisome linker polypeptide | | Authors: | He, Y, Eletsky, A, Mills, J.L, Lee, D, Ciccosanti, C, Hamilton, K, Acton, T.B, Xiao, R, Everett, J.K, Lee, H, Prestegard, J.H, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2010-05-14 | | Release date: | 2010-07-14 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of the PBS linker domain of phycobilisome linker polypeptide from Anabaena sp. Northeast Structural Genomics Consortium Target NsR123E
To be Published
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2KYY
 | | Solution NMR Structure of the N-terminal Domain of Putative ATP-dependent DNA Helicase RecG-related Protein from Nitrosomonas europaea, Northeast Structural Genomics Consortium Target NeR70A | | Descriptor: | Possible ATP-dependent DNA helicase RecG-related protein | | Authors: | Eletsky, A, Mills, J.L, Lee, H, Maglaqui, M, Ciccosanti, C, Hamilton, K, Rost, B, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Prestegard, J.H, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2010-06-09 | | Release date: | 2010-08-11 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Solution NMR Structure of the N-terminal Domain of Putative ATP-dependent DNA Helicase RecG-related Protein from Nitrosomonas europaea
To be Published
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2L3A
 | | Solution NMR structure of homodimer protein SP_0782 (7-79) from Streptococcus pneumoniae Northeast Structural Genomics Consortium Target SpR104 . | | Descriptor: | Uncharacterized protein | | Authors: | Yang, Y, Ramelot, T.A, Lee, D, Ciccosanti, C, Hamilton, K, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2010-09-10 | | Release date: | 2010-11-10 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of hepothetical homodimer protein SP_0782 (7-79) from Streptococcus pneumoniae, Northeast Structural Genomics Consortium Target SpR104
To be Published
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2LNI
 | | Solution NMR Structure of Stress-induced-phosphoprotein 1 STI1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4403E | | Descriptor: | Stress-induced-phosphoprotein 1 | | Authors: | Tang, Y, Liu, G, Hamilton, K, Ciccosanti, C, Shastry, R, Rost, B, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2011-12-28 | | Release date: | 2012-03-14 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Northeast Structural Genomics Consortium Target HR4403E
To be Published
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2LAH
 | | Solution NMR Structure of Mitotic checkpoint serine/threonine-protein kinase BUB1 N-terminal domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR5460A (Methods Development) | | Descriptor: | Mitotic checkpoint serine/threonine-protein kinase BUB1 | | Authors: | Liu, G, Xiao, R, Lee, H, Hamilton, K, Acton, T.B, Ciccosanti, C, Everett, J.K, Shastry, R.T, Huang, Y.J, Montelione, G.T, Northeast Structural Genomics Consortium, n, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2011-03-14 | | Release date: | 2011-05-11 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Northeast Structural Genomics Consortium Target HR5460A
To be Published
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2KZW
 | | Solution NMR Structure of Q8PSA4 from Methanosarcina mazei, Northeast Structural Genomics Consortium Target MaR143A | | Descriptor: | Uncharacterized protein | | Authors: | Mills, J.L, Eletsky, A, Lee, H, Lee, D, Ciccosanti, C, Hamilton, K, Acton, T.B, Xiao, R, Everett, J.K, Prestegard, J.H, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2010-06-25 | | Release date: | 2010-08-25 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Northeast Structural Genomics Consortium Target MaR143A
To be Published
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2LK2
 | | Solution NMR structure of homeobox domain (171-248) of human homeobox protein TGIF1, Northeast Structural Genomics Consortium Target HR4411B | | Descriptor: | Homeobox protein TGIF1 | | Authors: | Yang, Y, Ramelot, T.A, Cort, J.R, Shastry, R, Ciccosanti, C, Hamilton, K, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2011-09-30 | | Release date: | 2011-10-26 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of homeobox domain (171-248) of human homeobox protein TGIF1, Northeast Structural Genomics Consortium Target HR4411B.
To be Published
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2L9R
 | | Solution NMR Structure of Homeobox domain of Homeobox protein Nkx-3.1 from homo sapiens, Northeast Structural Genomics Consortium Target HR6470A | | Descriptor: | Homeobox protein Nkx-3.1 | | Authors: | Liu, G, Xiao, R, Lee, H.-W, Hamilton, K, Ciccosanti, C, Wang, H.B, Acton, T.B, Everett, J.K, Huang, Y.J, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2011-02-22 | | Release date: | 2011-04-20 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Solution NMR Structure of Homeobox domain of Homeobox protein Nkx-3.1 from homo sapiens, Northeast Structural Genomics Consortium Target HR6470A
To be Published
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1YRS
 | | Crystal structure of KSP in complex with inhibitor 1 | | Descriptor: | 3-[(5S)-1-ACETYL-3-(2-CHLOROPHENYL)-4,5-DIHYDRO-1H-PYRAZOL-5-YL]PHENOL, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | | Authors: | Cox, C.D, Breslin, M.J, Mariano, B.J, Coleman, P.J, Buser, C.A, Walsh, E.S, Hamilton, K, Kohl, N.E, Torrent, M, Yan, Y, Kuo, L.C, Hartman, G.D. | | Deposit date: | 2005-02-04 | | Release date: | 2005-04-12 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP
BIOORG.MED.CHEM.LETT., 15, 2005
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6BM0
 | | Cryo-EM structure of human CPSF-160-WDR33 complex at 3.8 A resolution | | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33 | | Authors: | Sun, Y, Zhang, Y, Hamilton, K, Walz, T, Tong, L. | | Deposit date: | 2017-11-12 | | Release date: | 2017-11-22 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Molecular basis for the recognition of the human AAUAAA polyadenylation signal.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6BLY
 | | Cryo-EM structure of human CPSF-160-WDR33 complex at 3.36A resolution | | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33 | | Authors: | Sun, Y, Zhang, Y, Hamilton, K, Walz, T, Tong, L. | | Deposit date: | 2017-11-12 | | Release date: | 2017-11-22 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.36 Å) | | Cite: | Molecular basis for the recognition of the human AAUAAA polyadenylation signal.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6DNH
 | | Cryo-EM structure of human CPSF-160-WDR33-CPSF-30-PAS RNA complex at 3.4 A resolution | | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, RNA (5'-R(P*AP*AP*UP*AP*AP*AP*C)-3'), ... | | Authors: | Sun, Y, Zhang, Y, Hamilton, K, Walz, T, Tong, L. | | Deposit date: | 2018-06-06 | | Release date: | 2018-06-27 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Molecular basis for the recognition of the human AAUAAA polyadenylation signal.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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1MZC
 | | Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a | | Descriptor: | 2-[3-(3-ETHYL-1-METHYL-2-OXO-AZEPAN-3-YL)-PHENOXY]-4-[1-AMINO-1-(1-METHYL-1H-IMIDIZOL-5-YL)-ETHYL]-BENZONITRILE, FARNESYL DIPHOSPHATE, Protein Farnesyltransferase alpha Subunit, ... | | Authors: | deSolms, S.J, Ciccarone, T.M, MacTough, S.C, Shaw, A.W, Buser, C.A, Ellis-Hutchings, M, Fernandes, C, Hamilton, K.A, Huber, H.E, Kohl, N.E, Lobell, R.B, Robinson, R.G, Tsou, N.N, Walsh, E.S, Graham, S.L, Beese, L.S, Taylor, J.S. | | Deposit date: | 2002-10-07 | | Release date: | 2003-07-08 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Dual Protein Farnesyltransferase-Geranylgeranyltransferase-I Inhibitors as Potential Cancer Chemotherapeutic Agents.
J.Med.Chem., 46, 2003
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2KVV
 | | Solution NMR of Putative excisionase from Klebsiella pneumoniae, Northeast Structural Genomics Consortium Target Target KpR49 | | Descriptor: | Putative excisionase | | Authors: | Liu, G, Xiao, R, Hamilton, K, Acton, T.B, Mao, B, Everett, J, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2010-03-28 | | Release date: | 2010-04-14 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Northeast Structural Genomics Consortium Target KpR49
To be Published
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