1MZC
Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a
Summary for 1MZC
Entry DOI | 10.2210/pdb1mzc/pdb |
Related | 1JCQ 1LD7 1LD8 |
Related PRD ID | PRD_900003 |
Descriptor | Protein Farnesyltransferase alpha Subunit, Protein Farnesyltransferase beta Subunit, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | alpha-alpha barrel, inhibitor, ftase, pftase, fpp, caax, ras, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 94948.87 |
Authors | deSolms, S.J.,Ciccarone, T.M.,MacTough, S.C.,Shaw, A.W.,Buser, C.A.,Ellis-Hutchings, M.,Fernandes, C.,Hamilton, K.A.,Huber, H.E.,Kohl, N.E.,Lobell, R.B.,Robinson, R.G.,Tsou, N.N.,Walsh, E.S.,Graham, S.L.,Beese, L.S.,Taylor, J.S. (deposition date: 2002-10-07, release date: 2003-07-08, Last modification date: 2024-02-14) |
Primary citation | DeSolms, S.J.,Ciccarone, T.M.,MacTough, S.C.,Shaw, A.W.,Buser, C.A.,Ellis-Hutchings, M.,Fernandes, C.,Hamilton, K.A.,Huber, H.E.,Kohl, N.E.,Lobell, R.B.,Robinson, R.G.,Tsou, N.N.,Walsh, E.S.,Graham, S.L.,Beese, L.S.,Taylor, J.S. Dual Protein Farnesyltransferase-Geranylgeranyltransferase-I Inhibitors as Potential Cancer Chemotherapeutic Agents. J.Med.Chem., 46:2973-2984, 2003 Cited by PubMed: 12825937DOI: 10.1021/jm020587n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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