4LYW

Crystal Structure of BRD4(1) bound to inhibitor XD14

Summary for 4LYW

Entry DOI	10.2210/pdb4lyw/pdb
Related	4LYI 4LYS 4LZR 4LZS
Descriptor	Bromodomain-containing protein 4, 4-acetyl-N-[5-(diethylsulfamoyl)-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide (3 entities in total)
Functional Keywords	brd4 inhibitor, bromodomain, epigenetic reader protein, acetylated lysine, histone tail, protein binding-inhibitor complex, protein binding/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O60885
Total number of polymer chains	1
Total formula weight	15504.89
Authors	Wohlwend, D.,Gerhardt, S.,Einsle, O. (deposition date: 2013-07-31, release date: 2014-01-15, Last modification date: 2024-02-28)
Primary citation	Lucas, X.,Wohlwend, D.,Hugle, M.,Schmidtkunz, K.,Gerhardt, S.,Schule, R.,Jung, M.,Einsle, O.,Gunther, S. 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew.Chem.Int.Ed.Engl., 52:14055-14059, 2013 Cited by PubMed: 24272870 DOI: 10.1002/anie.201307652 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation