7APO

Crystal structure of RARalpha ligand binding domain in complex with a fragment of the TIF2 coactivator

Summary for 7APO

Entry DOI	10.2210/pdb7apo/pdb
Descriptor	Retinoic acid receptor alpha, Nuclear receptor coactivator 2, 4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid, ... (5 entities in total)
Functional Keywords	nuclear hormone receptor, coactivator, transcription factor, retinoic acid, dna binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	63173.20
Authors	le Maire, A.,Guee, L.,Bourguet, W. (deposition date: 2020-10-19, release date: 2021-08-04, Last modification date: 2024-01-31)
Primary citation	Senicourt, L.,le Maire, A.,Allemand, F.,Carvalho, J.E.,Guee, L.,Germain, P.,Schubert, M.,Bernado, P.,Bourguet, W.,Sibille, N. Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR). J.Mol.Biol., 433:166899-166899, 2021 Cited by PubMed: 33647291 DOI: 10.1016/j.jmb.2021.166899 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation