7APO
Crystal structure of RARalpha ligand binding domain in complex with a fragment of the TIF2 coactivator
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0048384 | biological_process | retinoic acid receptor signaling pathway |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004879 | molecular_function | nuclear receptor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0048384 | biological_process | retinoic acid receptor signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue EQN A 501 |
| Chain | Residue |
| A | PHE199 |
| A | SER287 |
| A | PHE302 |
| A | GLY391 |
| A | HOH606 |
| A | PHE228 |
| A | LEU231 |
| A | SER232 |
| A | LEU266 |
| A | LEU269 |
| A | ILE270 |
| A | ARG276 |
| A | PHE286 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue EQN B 501 |
| Chain | Residue |
| B | PHE199 |
| B | PHE228 |
| B | LEU231 |
| B | SER232 |
| B | LEU269 |
| B | ILE273 |
| B | ARG276 |
| B | PHE286 |
| B | SER287 |
| B | PHE302 |
| B | GLY391 |
| B | VAL395 |
| B | LEU398 |
| B | HOH604 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| A | GLU357 |
| B | ARG364 |
| B | HIS372 |
| B | PHE374 |
| B | PRO375 |
| B | PRO403 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 801 |
| Chain | Residue |
| C | LYS705 |
| C | GLU709 |
| C | HOH902 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"UBR5-degron","evidences":[{"source":"PubMed","id":"37478846","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"3A9E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"20215566","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"19850744","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Motif: {"description":"9aaTAD","evidences":[{"source":"PubMed","id":"30468856","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Motif: {"description":"LXXLL motif 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
