7APO
Crystal structure of RARalpha ligand binding domain in complex with a fragment of the TIF2 coactivator
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Retinoic acid receptor alpha | polymer | 249 | 28078.5 | 2 | UniProt (P10276) Pfam (PF00104) | Homo sapiens (Human) | RAR-alpha,Nuclear receptor subfamily 1 group B member 1 |
| 2 | C, D (C, D) | Nuclear receptor coactivator 2 | polymer | 28 | 3064.6 | 2 | UniProt (E7EWM1) Pfam (PF08832) UniProt (by SIFTS) (Q15596) | Homo sapiens (Human) | |
| 3 | E, F (A, B) | 4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid | non-polymer | 351.4 | 2 | Chemie (EQN) | |||
| 4 | G, H (B, C) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 129 | Chemie (HOH) |
Sequence modifications
A, B: 176 - 421 (UniProt: P10276)
| PDB | External Database | Details |
|---|---|---|
| Gly 173 | - | expression tag |
| Ser 174 | - | expression tag |
| His 175 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62286.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 887.1 | |
| All* | Total formula weight | 63173.2 |
