4M49

Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18

Summary for 4M49

Entry DOI	10.2210/pdb4m49/pdb
Related	4JNK
Descriptor	L-lactate dehydrogenase A chain, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (7 entities in total)
Functional Keywords	dehydrogenase/reductase, nicotinamide adenine dinucleotide nadh, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00338
Total number of polymer chains	4
Total formula weight	151275.29
Authors	Eigenbrot, C.,Ultsch, M. (deposition date: 2013-08-06, release date: 2013-09-04, Last modification date: 2023-11-15)
Primary citation	Fauber, B.P.,Dragovich, P.S.,Chen, J.,Corson, L.B.,Ding, C.Z.,Eigenbrot, C.,Giannetti, A.M.,Hunsaker, T.,Labadie, S.,Liu, Y.,Liu, Y.,Malek, S.,Peterson, D.,Pitts, K.,Sideris, S.,Ultsch, M.,Vanderporten, E.,Wang, J.,Wei, B.,Yen, I.,Yue, Q. Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase. Bioorg.Med.Chem.Lett., 23:5533-5539, 2013 Cited by PubMed: 24012183 DOI: 10.1016/j.bmcl.2013.08.060 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.052 Å)

Structure validation