4M49

Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	L-lactate dehydrogenase A chain	polymer	331	36603.5	4	UniProt (P00338) Pfam (PF00056) Pfam (PF02866)	Homo sapiens (human)	LDH-A, Cell proliferation-inducing gene 19 protein, LDH muscle subunit, LDH-M, Renal carcinoma antigen NY-REN-59
2	E, I, L, P (A, B, C, D)	1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE	non-polymer		665.4	4	Chemie (NAI) PubChem (16219774) PubChem (928) PubChem (44119956) PubChem (44415182) PubChem (439153) PubChem (124934832) PubChem (126455899) PubChem (94865921) PubChem (94865923) PubChem (134693949) PubChem (12309339) PubChem (12309347) PubChem (124432988) PubChem (140875346) PubChem (11250888) PubChem (12309341) PubChem (124934831) PubChem (124934833) PubChem (162951601) PubChem (162951600) PubChem (164575491) PubChem (169545638) PubChem (170905224) PubChem (174316169) PubChem (129607000) PubChem (129628338) PubChem (146167236) PubChem (162951602) PubChem (174084875)
3	F, J, M (A, B, C)	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	3	Chemie (EPE) PubChem (23831)
4	G, N, Q (A, C, D)	3-(5-amino-6-{[(1R)-1-phenylethyl]amino}pyrazin-2-yl)-4-chlorobenzoic acid	non-polymer		368.8	3	Chemie (22Y) PubChem (71677802)
5	H, O, R (A, C, D)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
6	K (B)	LACTIC ACID	non-polymer		90.1	1	Chemie (LAC) PubChem (61503) PubChem (107689) PubChem (612)
7	S, T, U, V (A, B, C, D)	water	water		18.0	490	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	146413.9
Non-Polymers*	Number of molecules	14
	Total formula weight	4861.4
All*	Total formula weight	151275.3

*Water molecules are not included.