PDB: 35140 件ウェブページステータス検索Chemie searchBIRD

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6NBQ	T.elongatus NDH (data-set 1) 分子名称: IRON/SULFUR CLUSTER, NAD(P)H-quinone oxidoreductase chain 4 1, NAD(P)H-quinone oxidoreductase subunit 2, ... 著者 Laughlin, T.G, Bayne, A, Trempe, J.-F, Savage, D.F, Davies, K.M. 登録日 2018-12-09 公開日 2019-02-27 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structure of the complex I-like molecule NDH of oxygenic photosynthesis. Nature, 566, 2019
5NTI	Structural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds 分子名称: ASN-SER-HIS-GLN-LYS-VAL-THR-LEU-LEU-GLN-LEU-LEU-LEU-GLY-HIS-LYS-ASN-GLU-GLU-ASN, CHOLEST-5-EN-3-YL HYDROGEN SULFATE, Nuclear receptor ROR-gamma 著者 Kallen, J. 登録日 2017-04-28 公開日 2017-06-21 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural States of ROR gamma t: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds. ChemMedChem, 12, 2017
6NBO	Crystal structure of N-isopropylammelide isopropylaminohydrolase from Burkholderia multivorans ATCC 17616 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, N-isopropylammelide isopropylaminohydrolase, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2018-12-07 公開日 2018-12-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structure of N-isopropylammelide isopropylaminohydrolase from Burkholderia multivorans ATCC 17616 to be published
7TRE	Human telomerase catalytic core with shelterin protein TPP1 分子名称: Adrenocortical dysplasia protein homolog, Telomerase RNA, partial sequence, ... 著者 Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J. 登録日 2022-01-28 公開日 2022-04-20 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure of active human telomerase with telomere shelterin protein TPP1. Nature, 604, 2022
5NVN	Crystal structure of the human 4EHP-4E-BP1 complex 分子名称: Eukaryotic translation initiation factor 4E type 2, Eukaryotic translation initiation factor 4E-binding protein 1, FORMIC ACID 著者 Peter, D, Sandmeir, F, Valkov, E. 登録日 2017-05-04 公開日 2017-07-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression. Genes Dev., 31, 2017
5NVC	Crystal structure of TNKS2 in complex with 2-(3-hydroxyphenyl)-3,4-dihydroquinazolin-4-one 分子名称: 2-(3-hydroxyphenyl)-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-05-04 公開日 2018-03-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
5NWD	Crystal structure of TNKS2 in complex with 2-[4-(diethylamino)phenyl]-3,4-dihydroquinazolin-4-one 分子名称: 2-[4-(diethylamino)phenyl]-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-05-05 公開日 2018-03-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
6N3F	Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to SF3b1 ULM5 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, HIV Tat-specific factor 1, ... 著者 Leach, J.R, Jenkins, J.L, Kielkopf, C.L. 登録日 2018-11-15 公開日 2019-01-02 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.099 Å) 主引用文献 The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294, 2019
3NSD	Silver bound to the multicopper oxidase CueO (untagged) 分子名称: Blue copper oxidase cueO, COPPER (II) ION, OXYGEN ATOM, ... 著者 Montfort, W.R, Roberts, S.A, Singh, S.K. 登録日 2010-07-01 公開日 2011-08-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structures of multicopper oxidase CueO bound to copper(I) and silver(I): functional role of a methionine-rich sequence. J. Biol. Chem., 286, 2011
6MA8	Human CYP3A4 bound to PMSF 分子名称: 1,2-ETHANEDIOL, Cytochrome P450 3A4, DIMETHYL SULFOXIDE, ... 著者 Sevrioukova, I.F. 登録日 2018-08-26 公開日 2019-01-16 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Interaction of Human Drug-Metabolizing CYP3A4 with Small Inhibitory Molecules. Biochemistry, 58, 2019
6NUB	Pyruvate Kinase M2 Mutant - S437Y in Complex with L-serine 分子名称: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... 著者 Srivastava, D, Nandi, S, Dey, M. 登録日 2019-01-31 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2. Biochemistry, 58, 2019
6NRA	hTRiC-hPFD Class1 (No PFD) 分子名称: T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... 著者 Gestaut, D.R, Roh, S.H, Ma, B, Pintilie, G, Joachimiak, L.A, Leitner, A, Walzthoeni, T, Aebersold, R, Chiu, W, Frydman, J. 登録日 2019-01-23 公開日 2019-06-19 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (7.7 Å) 主引用文献 The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis. Cell, 177, 2019
5O8U	Covalent Inhibitor 4b bound to the Lipid Pocket of p38alpha Mutant S252C 分子名称: 4-[3-[7-azanyl-4-(2-phenylethylamino)quinazolin-2-yl]phenyl]butan-2-one, Mitogen-activated protein kinase 14 著者 Buehrmann, M, Rauh, D. 登録日 2017-06-14 公開日 2017-09-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Covalent Lipid Pocket Ligands Targeting p38 alpha MAPK Mutants. Angew. Chem. Int. Ed. Engl., 56, 2017
6NU1	Crystal Structure of Human PKM2 in Complex with L-cysteine 分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, CYSTEINE, MAGNESIUM ION, ... 著者 Srivastava, D, Nandi, S, Dey, M. 登録日 2019-01-30 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2. Biochemistry, 58, 2019
7S1T	Structure of the human POT1-TPP1 complex 分子名称: Adrenocortical dysplasia protein homolog, Protection of telomeres protein 1, ZINC ION 著者 Aramburu, T, Skordalakes, E. 登録日 2021-09-02 公開日 2022-01-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 POT1-TPP1 binding stabilizes POT1, promoting efficient telomere maintenance. Comput Struct Biotechnol J, 20, 2022
5O8V	Covalent Inhibitor 4a bound to the Lipid Pocket of p38alpha Mutant S251C 分子名称: Mitogen-activated protein kinase 14, ~{N}-[3-[7-azanyl-4-(2-phenylethylamino)quinazolin-2-yl]phenyl]propanamide 著者 Buehrmann, M, Rauh, D. 登録日 2017-06-14 公開日 2017-09-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Covalent Lipid Pocket Ligands Targeting p38 alpha MAPK Mutants. Angew. Chem. Int. Ed. Engl., 56, 2017
5O90	Crystal structure of a P38alpha T185G mutant in complex with TAB1 peptide. 分子名称: 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, Mitogen-activated protein kinase 14, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 著者 Nichols, C.E, De Nicola, G.F, Thapa, D. 登録日 2017-06-15 公開日 2018-01-31 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 TAB1-Induced Autoactivation of p38 alpha Mitogen-Activated Protein Kinase Is Crucially Dependent on Threonine 185. Mol. Cell. Biol., 38, 2018
5ND3	Microtubule-bound MKLP2 motor domain in the with no nucleotide 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF20A, ... 著者 Atherton, J, Yu, I.M, Cook, A, Muretta, J.M, Joseph, A.P, Major, J, Sourigues, Y, Clause, J, Topf, M, Rosenfeld, S.S, Houdusse, A, Moores, C.A. 登録日 2017-03-07 公開日 2017-10-04 実験手法 ELECTRON MICROSCOPY (6.1 Å) 主引用文献 The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry. Elife, 6, 2017
3OD3	CueO at 1.1 A resolution including residues in previously disordered region 分子名称: 1,2-ETHANEDIOL, Blue copper oxidase cueO, COPPER (II) ION, ... 著者 Montfort, W.R, Roberts, S.A, Singh, S.K. 登録日 2010-08-10 公開日 2011-09-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Crystal structures of multicopper oxidase CueO bound to copper(I) and silver(I): functional role of a methionine-rich sequence. J. Biol. Chem., 286, 2011
6N3W	Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound 5'-O-[3-Phenyl-1-Ethyl]Carbamoyl Guanosine 分子名称: 5'-O-[(2-phenylethyl)carbamoyl]guanosine, Histidine triad nucleotide-binding protein 1 著者 Strom, A.M, Finzel, B.C. 登録日 2018-11-16 公開日 2019-09-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Inhibition of HINT1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice. Acs Chem Neurosci, 10, 2019
6MJM	Substrate Free Cytochrome P450 3A5 (CYP3A5) 分子名称: Cytochrome P450 3A5, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE 著者 Hsu, M.H, Johnson, E.F. 登録日 2018-09-21 公開日 2019-04-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Active-site differences between substrate-free and ritonavir-bound cytochrome P450 (CYP) 3A5 reveal plasticity differences between CYP3A5 and CYP3A4. J.Biol.Chem., 294, 2019
5NP1	Open protomer of human ATM (Ataxia telangiectasia mutated) 分子名称: Serine-protein kinase ATM 著者 Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L. 登録日 2017-04-13 公開日 2017-05-17 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (5.7 Å) 主引用文献 Structures of closed and open conformations of dimeric human ATM. Sci Adv, 3, 2017
7U4T	Human V-ATPase in state 2 with SidK and mEAK-7 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, MTOR-associated protein MEAK7, ... 著者 Wang, L, Fu, T.M. 登録日 2022-03-01 公開日 2022-08-24 最終更新日 2023-09-06 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Identification of mEAK-7 as a human V-ATPase regulator via cryo-EM data mining. Proc.Natl.Acad.Sci.USA, 119, 2022
6NBX	T.elongatus NDH (data-set 2) 分子名称: IRON/SULFUR CLUSTER, NAD(P)H-quinone oxidoreductase chain 4 1, NAD(P)H-quinone oxidoreductase subunit 1, ... 著者 Laughlin, T.G, Bayne, A, Trempe, J.-F, Savage, D.F, Davies, K.M. 登録日 2018-12-10 公開日 2019-02-27 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure of the complex I-like molecule NDH of oxygenic photosynthesis. Nature, 566, 2019
6NRC	hTRiC-hPFD Class3 分子名称: Prefoldin subunit 1, Prefoldin subunit 2, Prefoldin subunit 3, ... 著者 Gestaut, D, Roh, S.H, Ma, B, Pintilie, G, Joachimiak, L.A, Leitner, A, Walzthoeni, T, Aebersold, R, Chiu, W, Frydman, J. 登録日 2019-01-23 公開日 2019-06-19 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (8.3 Å) 主引用文献 The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis. Cell, 177, 2019

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