5O90

Crystal structure of a P38alpha T185G mutant in complex with TAB1 peptide.

Summary for 5O90

Entry DOI	10.2210/pdb5o90/pdb
Descriptor	Mitogen-activated protein kinase 14, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, ... (4 entities in total)
Functional Keywords	mapk14 transferase tab1, transferase
Biological source	Mus musculus (Mouse) More
Cellular location	Cytoplasm : P47811
Total number of polymer chains	2
Total formula weight	44735.01
Authors	Nichols, C.E.,De Nicola, G.F.,Thapa, D. (deposition date: 2017-06-15, release date: 2018-01-31, Last modification date: 2024-01-17)
Primary citation	Thapa, D.,Nichols, C.,Bassi, R.,Martin, E.D.,Verma, S.,Conte, M.R.,De Santis, V.,De Nicola, G.F.,Marber, M.S. TAB1-Induced Autoactivation of p38 alpha Mitogen-Activated Protein Kinase Is Crucially Dependent on Threonine 185. Mol. Cell. Biol., 38:-, 2018 Cited by PubMed: 29229647 DOI: 10.1128/MCB.00409-17 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.49 Å)

Structure validation