5O90
Crystal structure of a P38alpha T185G mutant in complex with TAB1 peptide.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Mitogen-activated protein kinase 14 | polymer | 360 | 41294.1 | 1 | UniProt (P47811) Pfam (PF00069) In PDB | Mus musculus (Mouse) | MAPK 14,CRK1,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha |
2 | B | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | polymer | 29 | 3102.5 | 1 | UniProt (Q15750) In PDB | Homo sapiens | Mitogen-activated protein kinase kinase kinase 7-interacting protein 1,TGF-beta-activated kinase 1-binding protein 1,TAK1-binding protein 1 |
3 | A | 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE | non-polymer | 338.4 | 1 | Chemie (SB4) | |||
4 | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: P47811)
PDB | External Database | Details |
---|---|---|
Gly 185 | Thr 185 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 44396.6 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 338.4 | |
All* | Total formula weight | 44735.0 |