5O90
Crystal structure of a P38alpha T185G mutant in complex with TAB1 peptide.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 14 | polymer | 360 | 41294.1 | 1 | UniProt (P47811) Pfam (PF00069) | Mus musculus (Mouse) | MAPK 14,CRK1,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha |
| 2 | B (B) | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | polymer | 29 | 3102.5 | 1 | UniProt (Q15750) | Homo sapiens | Mitogen-activated protein kinase kinase kinase 7-interacting protein 1,TGF-beta-activated kinase 1-binding protein 1,TAK1-binding protein 1 |
| 3 | C (A) | 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE | non-polymer | 338.4 | 1 | Chemie (SB4) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: P47811)
| PDB | External Database | Details |
|---|---|---|
| Gly 185 | Thr 185 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44396.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 338.4 | |
| All* | Total formula weight | 44735.0 |
