5NWD

Crystal structure of TNKS2 in complex with 2-[4-(diethylamino)phenyl]-3,4-dihydroquinazolin-4-one

Summary for 5NWD

Entry DOI	10.2210/pdb5nwd/pdb
Descriptor	Tankyrase-2, 2-[4-(diethylamino)phenyl]-3~{H}-quinazolin-4-one, ZINC ION, ... (7 entities in total)
Functional Keywords	tankyrase, inhibitor, artd6, parp5b, adp-ribosyltransferase, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	55829.41
Authors	Nkizinkiko, Y.,Haikarainen, T.,Lehtio, L. (deposition date: 2017-05-05, release date: 2018-03-14, Last modification date: 2024-01-17)
Primary citation	Nkizinkiko, Y.,Desantis, J.,Koivunen, J.,Haikarainen, T.,Murthy, S.,Sancineto, L.,Massari, S.,Ianni, F.,Obaji, E.,Loza, M.I.,Pihlajaniemi, T.,Brea, J.,Tabarrini, O.,Lehtio, L. 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8:1680-1680, 2018 Cited by PubMed: 29374194 DOI: 10.1038/s41598-018-19872-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation