Crystal structure of the human 4EHP-4E-BP1 complex

Summary for 5NVN

DescriptorEukaryotic translation initiation factor 4E type 2, Eukaryotic translation initiation factor 4E-binding protein 1, FORMIC ACID, ... (4 entities in total)
Functional Keywordstranslational regulation, translation initiation, cap-binding protein, eif4e-binding protein 1, translation
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total molecular weight52946.55
Peter, D.,Sandmeir, F.,Valkov, E. (deposition date: 2017-05-04, release date: 2017-07-26, Last modification date: 2018-01-24)
Primary citation
Peter, D.,Weber, R.,Sandmeir, F.,Wohlbold, L.,Helms, S.,Bawankar, P.,Valkov, E.,Igreja, C.,Izaurralde, E.
GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.
Genes Dev., 31:1147-1161, 2017
PubMed: 28698298 (PDB entries with the same primary citation)
DOI: 10.1101/gad.299420.117
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.252200.3%14.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report