5NVN

Crystal structure of the human 4EHP-4E-BP1 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Eukaryotic translation initiation factor 4E type 2	polymer	189	21979.1	2	UniProt (O60573) Pfam (PF01652) In PDB	Homo sapiens (Human)	eIF4E type 2,Eukaryotic translation initiation factor 4E homologous protein,Eukaryotic translation initiation factor 4E-like 3,eIF4E-like protein 4E-LP,mRNA cap-binding protein 4EHP,h4EHP,mRNA cap-binding protein type 3
2	B, D	Eukaryotic translation initiation factor 4E-binding protein 1	polymer	38	4333.1	2	UniProt (Q13541) In PDB	Homo sapiens (Human)	eIF4E-binding protein 1,Phosphorylated heat- and acid-stable protein regulated by insulin 1,PHAS-I
3	A, C	FORMIC ACID	non-polymer		46.0	7	Chemie (FMT)
4		water	water		18.0	221	Chemie (HOH)

Sequence modifications

A, C: 52 - 234 (UniProt: O60573)

PDB	External Database	Details
Gly 46	-	expression tag
Pro 47	-	expression tag
His 48	-	expression tag
Met 49	-	expression tag
Leu 50	-	expression tag
Glu 51	-	expression tag

B, D: 50 - 83 (UniProt: Q13541)

PDB	External Database	Details
Gly 46	-	expression tag
Pro 47	-	expression tag
His 48	-	expression tag
Met 49	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	52624.4
Non-Polymers*	Number of molecules	7
	Total formula weight	322.2
All*	Total formula weight	52946.6

*Water molecules are not included.