5NVN
Crystal structure of the human 4EHP-4E-BP1 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003743 | molecular_function | translation initiation factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006413 | biological_process | translational initiation |
| B | 0008190 | molecular_function | eukaryotic initiation factor 4E binding |
| B | 0045947 | biological_process | negative regulation of translational initiation |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003743 | molecular_function | translation initiation factor activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006413 | biological_process | translational initiation |
| D | 0008190 | molecular_function | eukaryotic initiation factor 4E binding |
| D | 0045947 | biological_process | negative regulation of translational initiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue FMT A 301 |
| Chain | Residue |
| A | GLN93 |
| A | ARG96 |
| A | HOH439 |
| B | PRO72 |
| B | ASP74 |
| C | ASP198 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue FMT C 301 |
| Chain | Residue |
| B | ARG73 |
| C | THR199 |
| C | ARG202 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue FMT C 302 |
| Chain | Residue |
| B | ARG73 |
| C | PHE160 |
| C | MET161 |
| C | ARG195 |
| C | THR199 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue FMT C 303 |
| Chain | Residue |
| C | LEU139 |
| C | ARG140 |
| C | LEU143 |
| C | FMT304 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue FMT C 304 |
| Chain | Residue |
| C | GLU177 |
| C | FMT303 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue FMT C 305 |
| Chain | Residue |
| C | ARG146 |
| C | ASN150 |
| C | ASN205 |
| C | HOH416 |
| D | ARG56 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue FMT C 306 |
| Chain | Residue |
| C | LYS222 |
Functional Information from PROSITE/UniProt
| site_id | PS00813 |
| Number of Residues | 24 |
| Details | IF4E Eukaryotic initiation factor 4E signature. DFhlFKegIkPmWEDdanknGGKW |
| Chain | Residue | Details |
| A | ASP112-TRP135 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | Region: {"description":"EIF4EBP1/2/3 binding","evidences":[{"source":"PubMed","id":"17368478","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17368478","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P06730","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15); alternate","evidences":[{"source":"PubMed","id":"17289916","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)","evidences":[{"source":"PubMed","id":"17289916","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | Motif: {"description":"YXXXXLphi motif","evidences":[{"source":"UniProtKB","id":"P70445","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by DYRK2, MAPK1, MAPK3 and MTOR","evidences":[{"source":"PubMed","id":"12588975","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12747827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22578813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25702871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29750193","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by MTOR","evidences":[{"source":"PubMed","id":"12747827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22578813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25702871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29750193","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22578813","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
