5DG5
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![BU of 5dg5 by Molmil](/molmil-images/mine/5dg5) | CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET IN COMPLEX WITH ALTIRATINIB ANALOG DP-4157 | 分子名称: | Hepatocyte growth factor receptor, N-(2,5-difluoro-4-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxam ide | 著者 | Smith, B.D, Kaufman, M.D, Leary, C.B, Turner, B.A, Wise, S.A, Ahn, Y.M, Booth, R.J, Caldwell, T.M, Ensinger, C.L, Hood, M.M, Lu, W.-P, Patt, T.W, Patt, W.C, Rutkoski, T.J, Samarakoon, T, Telikepalli, H, Vogeti, L, Vogeti, S, Yates, K.M, Chun, L, Stewart, L.J, Clare, M, Flynn, D.L. | 登録日 | 2015-08-27 | 公開日 | 2016-08-31 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2. Mol.Cancer Ther., 14, 2015
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5DA3
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![BU of 5da3 by Molmil](/molmil-images/mine/5da3) | Crystal structure of PTK6 Kinase domain with inhibitor | 分子名称: | (2-chloro-4-{[6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone, GLYCEROL, Protein-tyrosine kinase 6 | 著者 | Thakur, M.K, Birudukota, S, Swaminathan, S, Battula, S.K, Vadivelu, S, Tyagi, R, Gosu, R. | 登録日 | 2015-08-19 | 公開日 | 2016-08-24 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Co-crystal structures of PTK6: With Dasatinib at 2.24 angstrom , with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 angstrom resolution Biochem. Biophys. Res. Commun., 482, 2017
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5D7V
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![BU of 5d7v by Molmil](/molmil-images/mine/5d7v) | Crystal structure of PTK6 kinase domain | 分子名称: | GLYCEROL, PHOSPHATE ION, Protein-tyrosine kinase 6 | 著者 | Thakur, M.K, Birudukota, S, Swaminathan, S, Tyagi, R, Gosu, R. | 登録日 | 2015-08-14 | 公開日 | 2016-08-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Crystal structure of the kinase domain of human protein tyrosine kinase 6 (PTK6) at 2.33 angstrom resolution Biochem.Biophys.Res.Commun., 478, 2016
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5D41
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![BU of 5d41 by Molmil](/molmil-images/mine/5d41) | EGFR kinase domain in complex with mutant selective allosteric inhibitor | 分子名称: | (2R)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenyl-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ... | 著者 | Yun, C.-H, Park, E, Eck, M.J. | 登録日 | 2015-08-07 | 公開日 | 2016-06-08 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors. Nature, 534, 2016
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5D12
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![BU of 5d12 by Molmil](/molmil-images/mine/5d12) | Kinase domain of cSrc in complex with RL40 | 分子名称: | N-[2-phenyl-4-(1H-pyrazol-3-ylamino)quinazolin-7-yl]prop-2-enamide, Proto-oncogene tyrosine-protein kinase Src | 著者 | Becker, C, Richters, A, Engel, J, Rauh, D. | 登録日 | 2015-08-03 | 公開日 | 2015-09-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach. J.Med.Chem., 58, 2015
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5D11
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![BU of 5d11 by Molmil](/molmil-images/mine/5d11) | Kinase domain of cSrc in complex with RL235 | 分子名称: | GLYCEROL, N-[3-({4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}oxy)phenyl]prop-2-enamide, Proto-oncogene tyrosine-protein kinase Src | 著者 | Becker, C, Gruetter, C, Engel, J, Rauh, D. | 登録日 | 2015-08-03 | 公開日 | 2015-09-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach. J.Med.Chem., 58, 2015
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5D10
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![BU of 5d10 by Molmil](/molmil-images/mine/5d10) | Kinase domain of cSrc in complex with RL236 | 分子名称: | N-[4-({4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}oxy)phenyl]prop-2-enamide, Proto-oncogene tyrosine-protein kinase Src | 著者 | Becker, C, Mayer-Wrangowski, S.C, Julian, E, Rauh, D. | 登録日 | 2015-08-03 | 公開日 | 2015-09-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach. J.Med.Chem., 58, 2015
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5CZI
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![BU of 5czi by Molmil](/molmil-images/mine/5czi) | |
5CZH
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![BU of 5czh by Molmil](/molmil-images/mine/5czh) | |
5CY3
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![BU of 5cy3 by Molmil](/molmil-images/mine/5cy3) | |
5CXZ
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![BU of 5cxz by Molmil](/molmil-images/mine/5cxz) | SYK catalytic domain complexed with naphthyridine inhibitor | 分子名称: | CHLORIDE ION, GLYCEROL, N-{7-[4-(dimethylamino)phenyl]-1,6-naphthyridin-5-yl}propane-1,3-diamine, ... | 著者 | Thoma, G, Veenstra, S, Strang, R, Blanz, J, Vangrevelinghe, E, Berghausen, J, Lee, C.C, Zerwes, H.-G. | 登録日 | 2015-07-29 | 公開日 | 2015-09-16 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Orally bioavailable Syk inhibitors with activity in a rat PK/PD model. Bioorg.Med.Chem.Lett., 25, 2015
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5CXH
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5CT7
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![BU of 5ct7 by Molmil](/molmil-images/mine/5ct7) | BRAF in Complex with RAF265 | 分子名称: | 1-methyl-5-({2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy)-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine, Serine/threonine-protein kinase B-raf | 著者 | Appleton, B.A. | 登録日 | 2015-07-23 | 公開日 | 2015-09-09 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.17 Å) | 主引用文献 | Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma. Acs Med.Chem.Lett., 6, 2015
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5CSX
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![BU of 5csx by Molmil](/molmil-images/mine/5csx) | CRYSTAL STRUCTURE OF B-RAF IN COMPLEX WITH BI 882370 | 分子名称: | N-(3-{5-[(1-ethylpiperidin-4-yl)(methyl)amino]-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl}-2,4-difluorophenyl)propane-1-sulfonamide, Serine/threonine-protein kinase B-raf, alpha-D-glucopyranose | 著者 | Bader, G, Stadtmuller, H, Steurer, S. | 登録日 | 2015-07-23 | 公開日 | 2016-03-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation. Mol.Cancer Ther., 15, 2016
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5CSW
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![BU of 5csw by Molmil](/molmil-images/mine/5csw) | B-RAF in complex with Dabrafenib | 分子名称: | CHLORIDE ION, Dabrafenib, Serine/threonine-protein kinase B-raf | 著者 | Bader, G, Stadtmuller, H, Steurer, S. | 登録日 | 2015-07-23 | 公開日 | 2016-03-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation. Mol.Cancer Ther., 15, 2016
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5CNO
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![BU of 5cno by Molmil](/molmil-images/mine/5cno) | Crystal structure of the EGFR kinase domain mutant V924R | 分子名称: | Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Kovacs, E, Das, R, Mirza, A, Jura, N, Barros, T, Kuriyan, J. | 登録日 | 2015-07-17 | 公開日 | 2015-07-29 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor. Mol.Cell.Biol., 35, 2015
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5CNN
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![BU of 5cnn by Molmil](/molmil-images/mine/5cnn) | Crystal structure of the EGFR kinase domain mutant I682Q | 分子名称: | Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Kovacs, E, Das, R, Mirza, A, Jura, N, Barros, T, Kuriyan, J. | 登録日 | 2015-07-17 | 公開日 | 2015-07-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor. Mol.Cell.Biol., 35, 2015
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5CF8
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![BU of 5cf8 by Molmil](/molmil-images/mine/5cf8) | CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL-10-ETHYL-7-[(3-METHOXYPROPYL)AMINO] -3-METHYL-3,5,8,10-TETRAAZATRICYCLO[7.3.0.0,6] DODECA-1(9),2(6),4,7,11-PENTAENE-11-CARBOXAMIDE | 分子名称: | N,N-dicyclopropyl-4-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide, Tyrosine-protein kinase JAK2 | 著者 | Sack, J.S. | 登録日 | 2015-07-08 | 公開日 | 2015-08-26 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms. Acs Med.Chem.Lett., 6, 2015
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5CF6
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![BU of 5cf6 by Molmil](/molmil-images/mine/5cf6) | CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL-10-[(2S)-2,3-DIHYDROXYPROPYL]-3-METHYL-7-(METHYLAMINO)-3,5,8,10-TETRAAZATRICYCLO [7.3.0.02,6]DODECA-1(9),2(6),4,7,11-PENTAENE-11-CARBOXAMIDE | 分子名称: | N,N-dicyclopropyl-6-[(2S)-2,3-dihydroxypropyl]-1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide, Tyrosine-protein kinase JAK2 | 著者 | Sack, J.S. | 登録日 | 2015-07-08 | 公開日 | 2015-08-26 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors. Acs Med.Chem.Lett., 6, 2015
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5CF5
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![BU of 5cf5 by Molmil](/molmil-images/mine/5cf5) | CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL-7-[(DIMETHYL-1,3-THIAZOL-2-YL)AMINO]-10-ETHYL-3-METHYL-3,5,8,10-TETRAAZATRICYCLO[7.3.0.02,6] DODECA-1(9),2(6),4,7,11-PENTAENE-11-CARBOXAMIDE | 分子名称: | N,N-dicyclopropyl-4-[(4,5-dimethyl-1,3-thiazol-2-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide, Tyrosine-protein kinase JAK2 | 著者 | Sack, J.S. | 登録日 | 2015-07-08 | 公開日 | 2015-08-26 | 最終更新日 | 2015-09-02 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors. Acs Med.Chem.Lett., 6, 2015
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5CF4
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![BU of 5cf4 by Molmil](/molmil-images/mine/5cf4) | CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL-10-ETHYL-7-[(3-METHOXYPROPYL)AMINO] -3-METHYL-3,5,8,10-TETRAAZATRICYCLO[7.3.0.0,6] DODECA-1(9),2(6),4,7,11-PENTAENE-11-CARBOXAMIDE | 分子名称: | N,N-dicyclopropyl-6-ethyl-4-[(3-methoxypropyl)amino]-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide, Tyrosine-protein kinase JAK2 | 著者 | Sack, J.S. | 登録日 | 2015-07-08 | 公開日 | 2015-08-26 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors. Acs Med.Chem.Lett., 6, 2015
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5CEQ
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![BU of 5ceq by Molmil](/molmil-images/mine/5ceq) | |
5CEP
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![BU of 5cep by Molmil](/molmil-images/mine/5cep) | |
5CEO
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![BU of 5ceo by Molmil](/molmil-images/mine/5ceo) | DLK in complex with inhibitor 2-((6-(3,3-difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile | 分子名称: | 2-[[6-[3,3-bis(fluoranyl)pyrrolidin-1-yl]-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile, Mitogen-activated protein kinase kinase kinase 12 | 著者 | HARRIS, S.F, YIN, J. | 登録日 | 2015-07-07 | 公開日 | 2015-10-14 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J.Med.Chem., 58, 2015
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5CEN
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![BU of 5cen by Molmil](/molmil-images/mine/5cen) | Crystal structure of DLK (kinase domain) | 分子名称: | Mitogen-activated protein kinase kinase kinase 12 | 著者 | HARRIS, S.F, YIN, J. | 登録日 | 2015-07-07 | 公開日 | 2015-10-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J.Med.Chem., 58, 2015
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