5CF6
CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL-10-[(2S)-2,3-DIHYDROXYPROPYL]-3-METHYL-7-(METHYLAMINO)-3,5,8,10-TETRAAZATRICYCLO [7.3.0.02,6]DODECA-1(9),2(6),4,7,11-PENTAENE-11-CARBOXAMIDE
Summary for 5CF6
Entry DOI | 10.2210/pdb5cf6/pdb |
Related | 5CF4 5CF5 5CF8 |
Descriptor | Tyrosine-protein kinase JAK2, N,N-dicyclopropyl-6-[(2S)-2,3-dihydroxypropyl]-1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide (3 entities in total) |
Functional Keywords | kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Endomembrane system ; Peripheral membrane protein : O60674 |
Total number of polymer chains | 2 |
Total formula weight | 76530.86 |
Authors | Sack, J.S. (deposition date: 2015-07-08, release date: 2015-08-26, Last modification date: 2017-11-22) |
Primary citation | Hart, A.C.,Schroeder, G.M.,Wan, H.,Grebinski, J.,Inghrim, J.,Kempson, J.,Guo, J.,Pitts, W.J.,Tokarski, J.S.,Sack, J.S.,Khan, J.A.,Lippy, J.,Lorenzi, M.V.,You, D.,McDevitt, T.,Vuppugalla, R.,Zhang, Y.,Lombardo, L.J.,Trainor, G.L.,Purandare, A.V. Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors. Acs Med.Chem.Lett., 6:845-849, 2015 Cited by PubMed: 26288682DOI: 10.1021/acsmedchemlett.5b00225 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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