5CZI

EGFR L858R MUTANT IN COMPLEX WITH A SHC PEPTIDE SUBSTRATE

Summary for 5CZI

Related5CZH
DescriptorEpidermal growth factor receptor, SHC Peptide substrate (3 entities in total)
Functional Keywordsegfr, l858r, kinase, egf, transferase
Biological sourceHomo sapiens (Human)
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Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted P00533
Total number of polymer chains2
Total molecular weight38955.67
Authors
Yun, C.H.,Eck, M.J. (deposition date: 2015-07-31, release date: 2015-09-30, Last modification date: 2015-12-23)
Primary citation
Begley, M.J.,Yun, C.H.,Gewinner, C.A.,Asara, J.M.,Johnson, J.L.,Coyle, A.J.,Eck, M.J.,Apostolou, I.,Cantley, L.C.
EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src.
Nat.Struct.Mol.Biol., 22:983-990, 2015
PubMed: 26551075 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb.3117
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.226120 7.1% 4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171916
PDB entries from 2020-12-02