5CZI
EGFR L858R MUTANT IN COMPLEX WITH A SHC PEPTIDE SUBSTRATE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 331 | 37676.5 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (B) | SHC Peptide substrate | polymer | 9 | 1279.2 | 1 | UniProt (by SIFTS) (P29353) | Escherichia coli H489 | SHC-TRANSFORMING PROTEIN 3, SHC-TRANSFORMING PROTEIN A, SRC HOMOLOGY 2 DOMAIN-CONTAINING-TRANSFORMING PROTEIN C1, SH2 DOMAIN PROTEIN C1 |
| 3 | C, D (A, B) | water | water | 18.0 | 129 | Chemie (HOH) |
Sequence modifications
A: 694 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 692 | - | expression tag |
| Ser 693 | - | expression tag |
| Arg 858 | Leu 858 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38955.7 | |
| All* | Total formula weight | 38955.7 |
