5DA3
Crystal structure of PTK6 Kinase domain with inhibitor
Summary for 5DA3
Entry DOI | 10.2210/pdb5da3/pdb |
Descriptor | Protein-tyrosine kinase 6, GLYCEROL, (2-chloro-4-{[6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone, ... (4 entities in total) |
Functional Keywords | ptk6, brk, complex, inhibitor, kinase, transferase, imidazo pyrazin, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q13882 |
Total number of polymer chains | 1 |
Total formula weight | 31236.44 |
Authors | Thakur, M.K.,Birudukota, S.,Swaminathan, S.,Battula, S.K.,Vadivelu, S.,Tyagi, R.,Gosu, R. (deposition date: 2015-08-19, release date: 2016-08-24, Last modification date: 2023-11-08) |
Primary citation | Thakur, M.K.,Birudukota, S.,Swaminathan, S.,Battula, S.K.,Vadivelu, S.,Tyagi, R.,Gosu, R. Co-crystal structures of PTK6: With Dasatinib at 2.24 angstrom , with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 angstrom resolution Biochem. Biophys. Res. Commun., 482:1289-1295, 2017 Cited by PubMed: 27993680DOI: 10.1016/j.bbrc.2016.12.030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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