5DA3
Crystal structure of PTK6 Kinase domain with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein-tyrosine kinase 6 | polymer | 265 | 30588.3 | 1 | UniProt (Q13882) Pfam (PF07714) | Homo sapiens (Human) | Breast tumor kinase,Tyrosine-protein kinase BRK |
| 2 | B, C (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 3 | D (A) | (2-chloro-4-{[6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone | non-polymer | 463.9 | 1 | Chemie (58V) | |||
| 4 | E (A) | water | water | 18.0 | 192 | Chemie (HOH) |
Sequence modifications
A: 185 - 446 (UniProt: Q13882)
| PDB | External Database | Details |
|---|---|---|
| Cxm 184 | - | expression tag |
| Thr 433 | Cys 433 | engineered mutation |
| His 447 | - | expression tag |
| His 448 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30588.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 648.1 | |
| All* | Total formula weight | 31236.4 |
